针刺治疗脓毒症胃肠功能障碍作用机制的研究进展  

Research Progress in Mechanism of Acupuncture in Treating Gastrointestinal Dysfunction in Sepsis

作　　者：赵佳瑶 梁群[2] 孙嘉婧 付晨菲 丛迪迪 王龙[1] ZHAO Jiayao;LIANG Qun;SUN Jiajing;FU Chenfei;CONG Didi;WANG Long(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Emergency and Critical Care Medicine,the First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院急诊及重症医学科,哈尔滨150040

出　　处：《医学综述》2023年第24期5780-5784,共5页Medical Recapitulate

基　　金：国家自然科学基金(81974557);哈尔滨市应用技术研究与开发项目(2017RAAXXJ037)。

摘　　要：脓毒症胃肠功能障碍是脓毒症高致病率、高死亡率的危重并发症,调控脓毒症胃肠功能对治疗脓毒症至关重要。针刺治疗能够有效调节胃肠症状并控制脓毒症发生发展,目前其涉及的作用机制主要包括调控促炎与抗炎反应扼制炎性风暴、调节神经-内分泌功能提高胃肠动力、调节免疫屏障增加免疫系统功能、修复黏膜结构提升机械屏障作用、纠正肠道菌群平衡微生态等方面。因此总结分析针刺改善脓毒症胃肠功能的作用机制,对未来进一步明确其起效机制具有重要意义,并且能为临床治疗提供科学理论依据、指导设计更加有效的诊疗方案。Gastrointestinal dysfunction in sepsis is a critical complication with high pathogenicity and mortality.Regulating the gastrointestinal function is crucial for the treatment of sepsis.Acupuncture treatment can effectively regulate gastrointestinal symptoms and control the occurrence and development of sepsis.Currently discovered mechanisms of action mainly include regulating pro-inflammatory and anti-inflammatory reactions to suppress inflammatory storms,regulating neuroendocrine function to improve gastrointestinal motility,modulating immune barrier to increase immune system function,repairing mucosal structure to enhance mechanical barrier function,correcting intestinal microbiota balance and microecology,and so on.Therefore,summarizing and analyzing the mechanism of acupuncture in improving gastrointestinal function in sepsis is of great significance for further clarifying its mechanism of action in the future,and can provide scientific theoretical basis for the clinical treatment and guide the design of more effective diagnosis and treatment plans.

关 键 词：脓毒症 胃肠功能障碍 针刺治疗 

分 类 号：R278[医药卫生—中医学] R245.31