血清生长分化因子15与冠状动脉慢血流现象以及动脉粥样硬化的相关性研究  

Correlation of serum growth differentiation factor-15 withcoronary slow flow phenomenon and atherosclerosis

作　　者：钱烨晟 殷骁 盛臻强[1] 黎叶飞[1] Qian Yesheng;Yin Xiao;Sheng Zhenqiang;Li Yefei(Department of Cardiovascular Medicine,Second Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China)

机构地区：[1]南通大学第二附属医院心血管内科,226001

出　　处：《中华老年心脑血管病杂志》2023年第10期1021-1024,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探究血清生长分化因子15(GDF-15)与冠状动脉慢血流现象(CSFP)、冠状动脉粥样硬化(AS)的相关性。方法选取2019年1月至2022年6月于南通大学第二附属医院住院并首次行冠状动脉造影的患者190例,分为CSFP组60例、AS组70例和冠状动脉血流正常(NC)组60例。收集所有患者一般资料、冠心病易患因素、临床生化指标、心电图等,采用酶联免疫吸附法测定患者血清GDF-15水平。结果年龄(OR=1.065,95%CI:1.014~1.119,P=0.021)、吸烟(OR=0.330,95%CI:0.132~0.823,P=0.001)和GDF-15(OR=1.006,95%CI:1.003~1.009,P=0.018)是AS的独立影响因素。年龄(OR=0.956,95%CI:0.926~0.988,P=0.024)和GDF-15(OR=1.003,95%CI:1.000~1.006,P=0.031)是CSFP的独立影响因素。中重度AS组GDF-15水平显著高于CSFP组、轻度AS组[(867.02±222.82)ng/Lvs(568.21±163.03)ng/L、(635.41±214.95)ng/L,P<0.01)。GDF-15与高敏C反应蛋白呈正相关(r=0.228,P=0.014)。结论GDF-15在CSFP组和AS组患者中呈现高表达;随着GDF-15水平的升高,AS程度逐渐加重;GDF-15与hs-CRP具有高度相关性。Objective To investigate the correlation of serum growth differentiation factor-15(GDF-15)with coronary slow flow phenomenon(CSFP)and coronary atherosclerosis(AS).Methods A total of 190 patients undergoing first-time coronary angiography in our hospital from January 2019 to June 2022 were recruited,and then according to definite diagnosis,divided into CSFP group(n=60),AS group(n=70)and NC group(normal coronary flow,n=60).Their gen-eral data,risk factors for coronary heart disease,clinical biochemical indexes and electrocardio-gram were collected.The serum GDF15 level was measured by ELISA.Results Age(OR=1.065,95%CI:1.014-1.119,P=0.021),smoking history(OR=0.330,95%CI:0.132-0.823,P=0.001)and GDF-15(OR=1.006,95%CI:1.003-1.009,P=0.018)were independent influencing factors of AS.Age(OR=0.956,95%CI:0.926-0.988,P=0.024)and GDF-15(OR=1.003,95%CI:1.000-1.006,P=0.031)were independent influencing factors of CSFP.The GDF-15 level was.significantly higher in the moderate or severe AS group than the CSFP group and the mild AS group(867.02±222.82 ng/L vs 568.21±163.03 ng/L and 635.41±214.95 ng/L,P<0.01).Serum GDF-15 level was positively correlated with hs CRP level(r=0.228,P=0.014).Conclusion GDF-15 is highly expressed in the patients with CSFP and with AS.With the increase of GDF-15.level,the severe the degree of AS gradually.GDF-15 is highly correlated with hs CRP.

关 键 词：生长分化因子15 动脉粥样硬化 数据相关性 冠状动脉造影 冠状动脉慢血流 

分 类 号：R541.4[医药卫生—心血管疾病]