白细胞介素6-572GC基因突变与河南汉族老年冠心病发病及严重程度的相关性  

Correlation of L-6-572GC mutation with incidence and severity of coronary heart disease in elderly Han people in Henan Province

作　　者：亓俊杰 李世勋 周凡 王岩 王志方 Qi Junjie;Li Shixun;Zhou Fan;Wang Yan;Wang Zhifang(De partment of Cardiovascular Diseases,Xinxiang Central Hospital,Forth Clinical College of Xinxiang Medical University,Xinriang 453000,Henan Province,China)

机构地区：[1]新乡市中心医院心血管内科、新乡医学院第四临床学院,453000

出　　处：《中华老年心脑血管病杂志》2023年第10期1025-1028,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：河南省科技攻关项目(212102310812)。

摘　　要：目的探讨白细胞介素6(IL-6)-572GC基因突变与河南汉族老年冠心病发病及严重程度的相关性。方法选择2020年1月至2022年12月新乡市中心医院收治的河南地区汉族老年冠心病患者446例为研究组,选取同期老年健康体检者218例为对照组。检测2组IL-6-174GC、IL-6-572GC和IL-6-597GA位点基因型,采用logistic回归分析IL-6-572GC基因多态性与老年冠心病的关系及IL-6-572GC位点基因型与冠心病严重程度的相关性。结果研究组高血压、糖尿病及LDL-C水平高于对照组,HDL-C水平低于对照组,差异有统计学意义(P<0.05,P<0.01)。IL-6-174GC位点存在3种基因型:GG、GC、CC,IL-6-572GC位点存在3种基因型:GG、GC、CC,IL-6-597GA位点存在3种基因型:GG、GA、AA。2组IL-6-174GC、IL-6-597GA基因型频率比较,差异无统计学意义(P>0.05);IL-6-572GC基因型频率比较,差异有统计学意义(P<0.01),研究组GG基因型频率明显低于对照组(33.18%vs46.82%,P<0.01)。Logistic回归分析显示,IL-6-572GC基因(OR=1.534,95%CI:1.180~1.995)、高血压(OR=1.442,95%CI:1.033~1.957)、糖尿病(OR=1.610,95%CI:1.083~2.391)、HDL-C(OR=0.467,95%CI:0.266~0.818)、LDL-C(OR=2.004,95%CI:1.104~3.636)均是冠心病发病的影响因素(P<0.05,P<0.01)。IL-6-572GC位点GG基因型单支病变率高于GC、CC基因型,3支病变率低于CC基因型,差异有统计学意义(P<0.05)。结论IL-6-572GC基因突变与河南汉族老年冠心病发病及严重程度存在相关性,IL-6-572GC基因突变会增加冠心病发病风险以及严重程度。Objective To investigate the correlation of IL-6-572GC mutation with the incidence and.severity of CHD in the Han elderly in Henan Province.Methods A total of 446 elderly CHD pa-tients of Han majority in Henan Province who were admitted to Department of Cardiovascular Diseases of our hospital from January 2020 to December 2022 were enrolled as the study group,and 218 healthy elderly patients taking physical examination in the same period were selected as the control group.The genotypes of IL-6-174GC,IL 6-572GC and IL-6-597GA were detected in the two groups.Logistic regression analysis was used to analyze the relationship between IL-6-572G/C gene polymorphism and CHD in the elderly,as well as the correlation between IL-6-572GC genotype and the severity of CHD.Results Larger proportions of hypertension and diabetes and higher LDL-C level,but lower HDL-C level were observed in the study group than the control group(P<0.05,P<0.01).There were three genotypes at IL-6-174GC locus(GG,GC and CC),three genotypes at IL-6-572GC locus(GG,GC and CC),and three genotypes at IL-6-597GA locus(GG,GA and AA).There were no significant differences in the genotype fre-quencies of IL-6-174GC and IL-6-597GA between the two groups(P>0.05),but there was a sig-nificant difference in the genotype frequency of IL-6-572GC(P<0.01)and the genotype frequen-cy of GG was significantly lower in the study group than the control group(33.18%vs 46.82%,P<0.01).Logistic regression analysis showed that IL-6-572GC(OR=1.534,95%CI:1.180-1.995),hypertension(OR=1.442,95%CI:1.033-1.957),diabetes(OR=1.610,95%CI:1.083-2.391),HDLC(OR=0.467,95%CI:0.266-0.818)and LDL-C(OR=2.004,95%CI:1.104-3.636)were all influencing factors of CHD(P<0.05,P<0.01).At IL-6-572GC locus,the inci-dence of single branch lesions was higher in the carriers of GG genotype than those of GC and CC genotypes,and the incidence of 3-branch lesions was lower than that of CC genotype(P<0.05).Conclusion The mutation of IL-6-572GC gene is correlated with the incidence and severity of CHD in the elderl

关 键 词：冠心病 基因型 白细胞介素6-572GC基因突变 IL-6-572GC基因多态性 基因型频率 

分 类 号：R541.4[医药卫生—心血管疾病]