老年冠状动脉扩张患者和白细胞与平均血小板体积比值的相关性研究  

Correlation between ratio of white blood cell to mean platelet volume and coronary artery ectasia in elderly patients

作　　者：付方方 陈欣[2] 邢璐宇 Fu Fangfang;Chen Xin;Xing Luyu(First Central Clinical College of Tianjin Medical University,Tianjin 300110,China)

机构地区：[1]天津医科大学一中心临床学院,300110 [2]天津市第一中心医院心脏科

出　　处：《中华老年心脑血管病杂志》2023年第10期1034-1037,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：天津市科技计划项目(22JCYBJC00720)。

摘　　要：目的研究老年冠状动脉扩张(coronary artery ectasia,CAE)患者和白细胞与平均血小板体积比值(WMR)的相关性。方法回顾性分析2018年1月1日至2023年1月1日天津市第一中心医院心内科接受冠状动脉造影(coronary angiography,CAG)的患者238例,根据CAG检查结果及年龄分为老年CAE组100例、非老年CAE组138例。根据CAG检查结果,选择同期年龄匹配的127例患者为老年冠状动脉正常组。检测所有患者WMR水平。结果老年CAE组WMR高于非老年CAE组和老年冠状动脉正常组[(745.50±237.46)vs(672.43±194.52)、(610.11±144.22),P=0.000]。Spearman相关性分析显示,WMR与血小板计数、中性粒细胞和高敏C反应蛋白呈正相关(r=0.380,P=0.000;r=0.819,P=0.000;r=0.283,P=0.000)。多因素logistic分析显示,再入院、男性、TC和WMR是老年CAE患者的独立危险因素(P<0.05,P<0.01)。WMR区分老年CAE患者的ROC曲线下面积为0.604(95%CI:0.531~0.677,P=0.006)。结论WMR升高有可能成为老年CAE患者中具有成本效益的监测指标。Objective To explore the correlation between CAE and the ratio of white blood cell.count to mean platelet volume ratio(WMR)in elderly patients.Methods A retrospective analysis was conducted on 238 patients who underwent coronary angiography(CAG)between January 2018 and January 2023 in Department of Cardiology of Tianjin First Central Hospital.According to the results of CAG and patient's age,they were divided into in elderly CAE group(age≥65 years,100 cases)and non-elderly CAE group(age<65 years,138 cases).Another 127 age-matched elderly individuals with normal coronary artery(age≥65 years)served as normal con-trol group.The WMR levels were measured in all participants.Results The elderly CAE group had significantly higher WMR than the non-elderly CAE group and the normal control group(745.50±237.46 vs 672.43±194.52 and 610.11±144.22,P=0.000).Spearman correlation analy-sis showed that W MR was positively correlated with platelet count,neutrophil count and high-sensitivity C-reactive protein level(r=0.380,P=0.000;r=0.819,P=0.000;r=0.283,P=0.000).Multiple logistic analysis indicated that readmission,male,TC and WMR were significantly associated with CAE in elderly patients.ROC curve analysis revealed that the value of WMR to distinguish the presence of CAE in elderly patients was 0.604(95%CI:0.531-0.677,P=0.006).Conclusion Elevated WMR might be a cost-effective monitor in elderly CAE patients..

关 键 词：冠状动脉疾病 数据相关性 回顾性研究 预测 冠状动脉扩张 白细胞与平均血小板体积比值 

分 类 号：R541.4[医药卫生—心血管疾病]