三拗片联合特布他林治疗咳嗽变异性哮喘临床研究  

Clinical Study on San'ao Tablets Combined with Terbutaline for Cough Varian Ashma

作　　者：陈琴[1] 柳桂菊 赵青青[1] 潘炯伟[1] CHEN Qin;LIU Guiju;ZHAO Qingqing;PAN Jiongwei(Department of Respiratory Medicine,Lishui People's Hospital,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市人民医院呼吸内科,浙江丽水323000

出　　处：《新中医》2023年第22期59-63,共5页New Chinese Medicine

摘　　要：目的:观察三拗片联合特布他林治疗咳嗽变异性哮喘的临床疗效。方法:选取80例咳嗽变异性哮喘患者为研究对象,随机分为对照组和治疗组各40例。对照组采用特布他林治疗,治疗组在对照组基础上加用三拗片治疗。观察2组临床疗效,以及治疗前后中医证候评分、肺功能指标[用力肺活量(FVC)、第1秒用力呼吸容积(FEV_(1))、最大呼吸流量(PFE)]、炎症指标[嗜酸性粒细胞计数、肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)]、莱斯特咳嗽问卷调查表(LCQ)评分的变化。结果:治疗组总有效率为95.00%,对照组为75.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组咳嗽、少痰、咽痒、流鼻涕等中医证候评分均较治疗前降低(P<0.05),且治疗组各项评分均低于对照组(P<0.05)。治疗后,2组FVC、FEV_(1)、PFE水平均较治疗前升高(P<0.05),且治疗组上述各项指标水平均高于对照组(P<0.05)。治疗后,2组嗜酸性粒细胞计数、TNF-α、IL-4水平均较治疗前降低(P<0.05),且治疗组上述各项指标水平均低于对照组(P<0.05)。治疗后,2组LCQ量表中生理、心理、社会评分及总分均较治疗前升高(P<0.05),且治疗组生理、心理评分及总分均高于对照组(P<0.05);而2组社会评分比较,差异无统计学意义(P>0.05)。结论:三拗片联合特布他林治疗咳嗽变异性哮喘能显著改善中医证候,减轻机体炎症反应,提高肺功能,改善患者心理状态和生活质量。Objective:To observe the clinical effect of the therapy of San'ao Tablets combined with Terbutaline on cough variant asthma.Methods:A total of 80 patients with cough variant asthma were selected as the study objects and randomly divided into the control group and the treatment group,with 40 cases in each group.The control group was given Terbutaline for treatment,and the treatment group was additionally treated with San'ao Tablets based on the treatment of the control group.The clinical effects,and the changes in traditional Chinese medicine(TCM)syndrome scores,indexes of lung function,including forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))and peak expiratory volume(PEV),and inflammatory indicators,including the number of eosinophilic granulocytes,tumor necrosis factor-α(TNF-α)and interleukin-4(IL-4),leicester cough questionnaire(LCQ)were observed before and after treatment in both groups.Results:The total effective rate was 95.00%in the treatment group and 75.00%in the control group,the difference being significant(P<0.05).After treatment,TCM syndrome scores of cough,scanty phlegm,throat itching and running nose in both groups were decreased when compared with those before treatment(P<0.05),and the above scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of FVC,FEV_(1)and PFE in both groups were increased when compared with those before treatment(P<0.05),and the above indexes in the treatment group were higher than those in the control group(P<0.05).After treatment,the number of eosinophilic granulocytes,and the levels of TNF-αand IL-4 in both groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the treatment group were lower than those in the control group(P<0.05).After treatment,the scores of physiology,psychology and society and total scores in LCQ scale in both groups were increased when compared with those before treatment(P<0.05),and the scores of physiology and psychology an

关 键 词：咳嗽变异性哮喘 三拗片 特布他林 肺功能 炎症因子 

分 类 号：R562.2[医药卫生—呼吸系统]