毓麟衍宗汤联合雌孕激素序贯疗法治疗肝郁肾虚型卵巢早衰临床研究  

Clinical Study on Yulin Yanzong Decoction Combined with Estrogen-Progesterone Sequential Therapy for Premature Ovarian Failure of Liver Depression and Kidney Deficiency Type

作　　者：郭彩玲 李瑞芹 李兴华 GUO Cailing;LI Ruiqin;LI Xinghua(Chinese Medicine Hospital of Puyang,Puyang Henan 457000,China)

机构地区：[1]濮阳市中医医院,河南濮阳457000

出　　处：《新中医》2023年第22期105-110,共6页New Chinese Medicine

摘　　要：目的:观察毓麟衍宗汤联合雌孕激素序贯疗法治疗肝郁肾虚型卵巢早衰的效果。方法:选取92例肝郁肾虚型卵巢早衰患者,依据随机数字表法分为观察组和对照组各46例。2组均给予雌孕激素序贯疗法治疗,观察组加予毓麟衍宗汤治疗,2组均治疗3个月经周期。治疗前后评定中医证候积分,检测性激素指标[卵泡雌激素(FSH)、黄体生成素(LH)、雌激素(E_(2))]、窦卵泡数和子宫内膜厚度,比较2组的临床疗效、治疗期间的不良反应发生率和随访6个月的月经复潮率。结果:治疗后,观察组临床疗效优于对照组,总有效率高于对照组,差异均有统计学意义(P<0.05)。2组中医证候积分均较治疗前降低(P<0.05);观察组中医证候积分低于对照组(P<0.05)。2组FSH、LH水平均较治疗前降低(P<0.05),E_(2)水平均较治疗前升高(P<0.05);观察组FSH、LH水平均低于对照组(P<0.05),E_(2)水平高于对照组(P<0.05)。2组窦卵泡数及子宫内膜厚度均较治疗前增加(P<0.05);观察组窦卵泡数多于对照组,子宫内膜厚度值高于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。随访6个月,观察组月经复潮率高于对照组(P<0.05)。结论:将毓麟衍宗汤与雌孕激素序贯疗法联合应用于肝郁肾虚型卵巢早衰患者的治疗中,可有效改善患者的临床症状和卵巢功能,调节内分泌失调状态,促进月经来潮,安全性良好。Objective:To observe the effect of Yulin Yanzong Decoction combined with estrogenprogesterone sequential therapy for premature ovarian failure of liver depression and kidney deficiency type.Methods:A total of 92 cases of patients with premature ovarian failure of liver depression and kidney deficiency type were selected and divided into the observation group and the control group according to the random number table method,with 46 cases in each group.Both groups were treated with estrogenprogesterone sequential therapy,and the observation group was additionally treated with Yulin Yanzong Decoction.Both groups were treated for three menstrual cycles.Before and after treatment,traditional Chinese medicine(TCM)syndrome scores were assessed;sex hormone indexes[follicle stimulating hormone(FSH),luteinizing hormone(LH),estrogen(E_(2))],number of antral follicles and endometrial thickness were detected.The incidence of adverse reactions during treatment,the rate of menstruation recovery during 6 months of follow-up and the clinical effects were compared between the two groups.Results:After treatment,the curative effect in the observation group was better than that in the control group(P<0.05),and the total effective rate was higher than that in the control group,differences being significant(P<0.05).TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05).The levels of FSH and LH in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of E_(2)were increased when compared with those before treatment(P<0.05).The levels of FSH and LH in the observation group were lower than those in the control group(P<0.05),and the level of E_(2)in the observation group was higher than that in the control group(P<0.05).The number of antral follicles and the endometrial thickness in the two groups were increased when compared with those before treatment(

关 键 词：卵巢早衰 肝郁肾虚证 毓麟衍宗汤 性激素 月经复潮 

分 类 号：R711.75[医药卫生—妇产科学]