低分子肝素钙用于高危产妇剖宫产术后静脉血栓形成预防中对APTT及TT水平的影响  

Impacts of Low Molecular Weight Heparin Calcium on APTT and TT Levels in the Prevention of Venous Thrombosis after Cesarean Section in High-risk Pregnant Women

作　　者：陈珂 CHEN Ke(Department of Pharmacy,Luoyang Maternal and Child Health Hospital,Luoyang Henan 471000,China)

机构地区：[1]洛阳市妇幼保健院药学部,河南洛阳471000

出　　处：《临床研究》2024年第2期62-65,共4页Clinical Research

摘　　要：目的探究低分子肝素用于高危产妇剖宫产术后静脉血栓形成预防中对凝血活酶时间(APTT)及凝血酶时间(TT)水平的影响。方法选取洛阳市妇幼保健院2021年1月至2023年1月接受剖宫产手术治疗高危产妇146例作为本次研究对象,按照随机数表法分为两组各73例,对照组接受下肢气压泵治疗,观察组接受下肢气压泵联合低分子钙素钙治疗,对比两组治疗前后凝血功能、血小板指标、下肢肿胀及出血风险性。结果两组术前凝血功能、血小板对比差异无统计学意义(P>0.05),观察组术后APTT、凝血酶原时间(PT)、TT高于对照组,纤维蛋白原(FIB)、血小板(PLT)低于对照组,差异有统计学意义(P<0.05);观察组Ⅰ级、Ⅱ级下肢肿胀发生率低于对照组,差异有统计学意义(P<0.05);两组发生出血的患者均为1例,出血的风险对比差异无统计学意义(P>0.05)。结论高危产妇经剖宫产术后预防性应用低分子肝素钙治疗效果良好,能有效调节凝血功能指标,预防术后静脉血栓形成,且不会增加出血风险,安全性较高。Objective To study the impacts of low molecular weight heparin calcium on activated partial thromboplastin time(APTT)and thrombin time(TT)in the prevention of venous thrombosis after cesarean section in high-risk pregnant women.Methods A total of 146 high-risk pregnant women of undergoing the cesarean section from January 2021 to January 2023 in our hospital were chosen as research subjects.According to random number table,women were assigned to control group(n=73,lower limb pneumatic pump)and observation group(n=73,lower limb pneumatic pump and low molecular weight heparin calcium).The coagulation function,platelet indices,lower extremity swelling,and risk of bleeding were compared between the two groups before and after treatment.Results There was no statistically significant difference in preoperative coagulation function and platelet count between the two groups(P>0.05);after surgery,APTT,prothrombin time(PT)and TT values in the observation group were higher than control group;the fibrinogen(FIB)and platelet count were lower than control group,with statistically significant difference(P<0.05).after surgery,grade Ⅰ,Ⅱ lower extremity swelling rates in the observation group were lower than control group,with statistically significant difference(P<0.05);the bleeding risks between observation group(one case)and control group(one case)were not significantly different(P>0.05).Conclusion The preventive uses of low molecular weight heparin calcium in high-risk pregnant women after cesarean section can adjust the coagulation function indicators and effectively prevent the venous thrombosis,produce less impact on the bleeding risks,increase the treatment effects and safety.It is worthy of clinical application.

关 键 词：低分子肝素钙 高危产妇 剖宫产 静脉血栓 下肢气压泵 

分 类 号：R713[医药卫生—妇产科学]