高频重复经颅磁刺激治疗帕金森病认知功能障碍患者的临床效果  

Clinical Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Cognitive Dysfunction in Patients with Parkinson’s Disease

作　　者：王煜姝[1] 马花 张康 WANG Yushu;MA Hua;ZHANG Kang(Department of Neurophysiology,Zhengzhou People’s Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州人民医院神经电生理科,河南郑州450000

出　　处：《临床研究》2024年第2期82-85,共4页Clinical Research

摘　　要：目的探究对帕金森病认知功能障碍患者使用高频重复经颅磁刺激治疗的临床效果。方法选取82例帕金森病认知功能障碍患者,均为郑州人民医院2022年1月至2023年5月收入,按随机数表法分为对照组与研究组,各41例。以左前额叶背外侧皮质为刺激区域,对照组41例患者使用高频重复经颅磁刺激(25 Hz)假性刺激治疗,研究组41例患者使用高频重复经颅磁刺激(25 Hz)真性刺激治疗。将两组患者临床治疗前后的认知障碍水平、P300变化及心理水平进行比较。结果研究组与对照组患者在治疗前蒙特利尔认知(MoCA)评分差异无统计学意义(P>0.05)。研究组患者治疗1个月、3个月后MoCA评分高于对照组患者,差异均有统计学意义(P<0.05)。治疗前研究组和对照组P300波幅与潜伏期差异无统计学意义(P>0.05)。治疗后研究组P300波幅明显升高,潜伏期降低,与对照组相比差异具有统计学意义(P<0.05)。治疗前两组患者汉密尔顿焦虑评分(HAMA)与汉密尔顿抑郁(HAMD)评分差异无统计学意义(P>0.05)。治疗后与对照组相比,研究组HAMA与HAMD评分下降,差异均有统计学意义(P<0.05)。结论高频重复经颅磁刺激是一种有效的治疗帕金森病认知功能障碍的方法,通过调控特定脑区的神经活动,改善患者认知功能水平,同时改善患者心理水平。Objective To explore the clinical effect of high-frequency repetitive transcranial magnetic stimulation in the treatment of cognitive dysfunction in patients with Parkinson’s disease.Methods A total of 82 patients with cognitive dysfunction in Parkinson’s disease were selected from January 2022 to May 2023 in our hospital.They were divided into control group and research group,each with 41 cases,according to the random number table method.The left dorsolateral prefrontal cortex was used as the stimulation area.The control group of 41 patients received sham stimulation treatment with high-frequency repetitive transcranial magnetic stimulation(25 Hz),and the research group of 41 patients received real stimulation treatment with highfrequency repetitive transcranial magnetic stimulation(25 Hz).The cognitive dysfunction level,P300 changes,and psychological level before and after clinical treatment of the two groups of patients were compared.Results There was no significant difference in the Montreal Cognitive Assessment(MoCA)score between the research group and the control group before treatment(P>0.05).The MoCA score of the patients in the research group was higher than that of the control group after 1 month and 3 months of treatment,and the difference was statistically significant(P<0.05).There was no significant difference in P300 amplitude and latency between the research group and the control group before treatment(P>0.05).After treatment,the P300 amplitude of the research group significantly increased and the latency decreased,which was statistically significant compared with the control group(P<0.05).There was no significant difference in the Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)scores between the two groups of patients before treatment(P>0.05).After treatment,the HAMA and HAMD scores of the research group decreased compared with the control group,and the difference was statistically significant(P<0.05).Conclusion High-frequency repetitive transcranial magnetic stim

关 键 词：认知功能障碍 帕金森病 高频重复经颅磁刺激 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]