头孢哌酮舒巴坦联合吸入布地奈德对细菌性肺炎的治疗效果及对患者炎症因子表达的影响  

Therapeutic Efficacy of Cefoperazone Sulbactam Combined with Inhaled Budesonide in Bacterial Pneumonia and the Effect on the Expression of Inflammatory Factors in Patients

作　　者：李晓琳[1] 朱惠源[1] LI Xiaolin;ZHU Huiyuan(Department of Respiratory and Critical Care Medicine,Zhengzhou Second People's Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州市第二人民医院呼吸与危重症医学科,河南郑州450000

出　　处：《临床研究》2024年第2期88-91,共4页Clinical Research

摘　　要：目的探究头孢哌酮舒巴坦联合布地奈德吸入治疗细菌性肺炎效果。方法选择2021年12月至2023年6月在郑州市第二人民医院治疗的细菌性肺炎患者82例,应用随机数表法将其分为对照组(头孢哌酮舒巴坦)及观察组(头孢哌酮舒巴坦联合布地奈德吸入)各41例,对比两组临床疗效、症状消失时间、血气指标(血氧分压、氧合指数、血氧饱和度)、炎症因子[白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)]、不良反应。结果观察组治疗有效率高于对照组,差异具有统计学意义(P<0.05)。观察组发热、咳嗽、肺啰音消失时间短于对照组,差异有统计学意义(P<0.05)。观察组血氧分压、氧合指数、血氧饱和度高于对照组,差异有统计学意义(P<0.05)。观察组IL-6、TNF-α、CRP低于对照组、IL-10高于对照组,差异均有统计学意义(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论细菌性肺炎患者接受头孢哌酮舒巴坦联合布地奈德吸入治疗,能够抑制炎症反应,改善血气指标,促进康复,且安全性较高。Objective To investigate the effect of cefoperazone sulbactam combined with budesonide inhalation in the treatment of bacterial pneumonia.Methods A total of 82 patients with bacterial pneumonia treated at the Second People's Hospital of Zhengzhou City from December 2021 to June 2023 were selected and divided into 41 cases each in the control group(cefoperazone sulbactam)and the observation group(combined with budesonide inhalation)by applying the random number table method,and the two groups were compared in terms of clinical efficacy,time of symptomatic improvement,blood gas indexes(partial pressure of blood oxygen,oxygenation index,oxygen saturation),inflammatory factors[interleukin-10(IL-10),interleukin-6(IL-6),tumour necrosis factor(TNF-α),C-reactive protein(CRP)],and adverse reactions.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The time of fever,cough and disappearance of pulmonary rales in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05).The partial pressure of blood oxygen,oxygenation index and oxygen saturation of the observation group were higher than that of the control group,the difference was statistically significant(P<0.05).IL-6,TNF-α,CRP of the observation group were lower than that of the control group,and IL-10 was higher than that of the control group,the difference was statistically significant(P<0.05).The difference in adverse reactions between the observation group and the control group was not statistically significant(P>0.05).Conclusion Bacterial pneumonia in patient receiving cefoperazone sulbactam combined with budesonide inhalation therapy,improve the patients'blood gas indexes,and promote recovery,and it is safe.

关 键 词：头孢哌酮舒巴坦 布地奈德吸入治疗 肺炎 炎症因子 

分 类 号：R563.1[医药卫生—呼吸系统]