喜炎平注射液联合抗生素治疗对老年肺气肿合并肺部感染的应用价值  

The Application Value of Xiyanping Injection Combined with Antibiotics in theTreatment of Elderly Emphysema with Pulmonary Infection

作　　者：徐贵银 XU Guiyin(Department of Respiratory Medicine,Pingyu County Central Hospital,Zhumadian Henan 463400,China)

机构地区：[1]平舆县中心医院呼吸内科,河南驻马店463400

出　　处：《临床研究》2024年第2期95-98,共4页Clinical Research

摘　　要：目的分析喜炎平注射液加头孢哌酮钠舒巴坦钠对老年肺气肿伴肺部感染患者的疗效。方法选取2021年1月至2022年8月期间在平舆县中心医院收治的老年肺气肿伴肺部感染患者86例为研究对象,根据随机数表法分为两组各43例,对照组采取头孢哌酮钠舒巴坦钠,观察组在对照组基础上采取喜炎平注射液,治疗后对两组临床疗效、体征及症状消失与住院时间、一秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、第一秒钟用力呼气容积与用力肺活量的比值(FEV_(1)/FVC)、肺活量(VC)、血白细胞计数(WBC)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及C-反应蛋白(CRP)及不良反应情况进行比较。结果观察组的缓解率(95.35%)高于对照组(76.74%),差异有统计学意义(P<0.05)。观察组咳嗽消失时间、气喘消失时间、湿啰音消失时间、哮鸣音消失时间、发热消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组FEV_(1)、FVC、FEV_(1)/FVC、VC水平均有所升高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组WBC、IL-6、IL-8、CRP水平均有所降低,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应(腹泻、恶心、心悸、皮疹)比较,差异无统计学意义(P>0.05)。结论喜炎平注射液加头孢哌酮钠舒巴坦钠对老年肺气肿伴肺部感染患者疗效理想,能促进其症状消失,改善其肺功能,减少其炎症因子分泌,缩短其住院时间,且安全性较高,值得采用。Objective To analyze the clinical effectiveness of Xiyanping injection with cefoperazone sodium and sulbactam sodium in elderly emphysema patients with pulmonary infections.Methods A total of 86 elderly patients with emphysema with pulmonary infection admitted to Pingyu County Central Hospital from January 2021 to August 2022 were selected as the study objects.There were 43 cases in each group according to random number table method.the control group was treated with cefoperazone sodium and sulbactam sodium;the observation group was treated with Xiyanping injection,cefoperazone sodium and sulbactam sodium.Group comparison results were observed through the clinical effects,sign and symptom disappearance time,hospital stays,forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),The ratio of forced expiratory volume in the first second to forced Vital capacity(FEV_(1)/FVC),vital capacity(VC),white blood cell count(WBC),Interleukin-6(IL-6),Interleukin-8(IL-8),C-reactive protein(CRP)and adverse drug reactions.Results The clinical remission rates in the observation group(95.35%)were higher than control group(76.74%),the difference was statistically significant(P<0.05);The disappearance time of cough,asthma,rales,wheezing,fever and hospitalization in the observation group were shorter than those in the control group,with statistical significance(P<0.05).After treatment,the levels of FEV_(1),FVC,FEV_(1)/FVC and VC in both groups were increased,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of WBC,IL-6,IL-8 and CRP in both groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions(diarrhea,nausea,palpitation and rash)between the two groups(P>0.05).Conclusion Xiyangping injection plus cefoperazone sodium and sulbactam sodium have ideal curative effect on elderly patients with emphys

关 键 词：肺气肿 肺部感染 喜炎平注射液 头孢哌酮钠舒巴坦钠 

分 类 号：R563.3[医药卫生—呼吸系统]