快速启动高效抗反转录病毒治疗对较高CD4^(+)T淋巴细胞的人类免疫缺陷病毒感染-艾滋病患者治疗依从性及预后的影响  

Effect of rapid initiation of highly active antiretroviral therapy on treatment compliance and prognosis of human immunodeficiency virus infected acquired immune deficiecy syndrome patients with high CD4^(+)T lymphocvtes

作　　者：周敏 况玲芝 刘敏 ZHOU Min;KUANG Lingzhi;LIU Min(Department of Infectious Diseases,Jiangxi Xinyu People's Hospital,Jiangxi Province,Xinyu 338000,China)

机构地区：[1]江西省新余市人民医院感染科,江西新余338000

出　　处：《中国当代医药》2024年第1期23-26,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202212236)。

摘　　要：目的探讨快速启动高效抗反转录病毒治疗(HAART)对较高CD4^(+)T淋巴细胞的人类免疫缺陷病毒感染-艾滋病(HIVAIDS)患者治疗依从性及预后的影响。方法选取2021年7月至12月在新余市人民医院感染科住院和艾滋病门诊就诊的HIVAIDS患者61例,将确诊7d以内及时就诊且知情同意下启动抗病毒治疗的32例患者设为快速启动组,将确诊后未及时转至艾滋病门诊或转来后未接受快速启动HAART的患者29例设为未接受快速启动组。记录两组患者的基线病毒载量(HIV-RNA)及CD4^(+)T淋巴细胞计数以及抗病毒治疗6、12个月病毒载量及CD4T淋巴细胞计数,并记录入组患者治疗依从性、病毒抑制率、失访率。结果快速启动组治疗6、12个月的CD4^(+)T淋巴细胞计数高于未接受快速启动组,差异有统计学意义(P<0.05);快速启动组治疗6、12个月的HIV-RNA低于未接受快速启动组,差异有统计学意义(P<0.05);快速启动组的治疗依从性和病毒抑制率高于未接受快速启动组,失访率低于未接受快速启动组,差异有统计学意义(P<0.05)。结论快速启动(确诊7d以内)HAART能最大程度提高较高CD4^(+)T淋巴细胞的HIV/AIDS患者抗病毒治疗依从性,提高病毒抑制率、CD4^(+)T淋巴细胞计数水平,并能减少失访率,值得临床推广。Objective To investigate the effect of rapid initiation of highly active antiretroviral therapy(HAART)on the treatment compliance and prognosis of human immunodeficiency virus infected acquired immune deficiecy syndrome(HIVAIDS)patients with high CD4^(+)T lymphocytes.Methods From July to December 2021,61 HIVAIDS patients hospitalized in Department of Infectious Diseases,Jiangxi Xinyu People's Hospital were selected.32 patients who went to the hospital in time within 7 days after diagnosis and started antiviral treatment with informed consent were set as the fast start group.29 patients who did not go to the AIDS clinic in time after diagnosis or did not receive the fast start HAART afer transfer were set as the fast start group.The baseline viral load(HIV-RNA)and CD4^(+)T lymphocyte count of two groups of patients,as well as the viral load and CD4^(+)T lymphocyte count were recorded afier 6 and 12 months of antiviral treatment,and the treatment compliance,virus inhibition rate,and follow-up loss rate of the enrolled patients were recorded.Results The the CD4^(+)T lymphocyte count in the rapid start group was higher than that in the non rapid start group at 6 and 12 months of treatment,with statistically significant difference(P<0.05).After 6 and 12 months of treatment,the HIV-RNA level of the two group was lower than before treatment,while the HIV-RNA level in the rapid start group was lower than those in the non rapid start group at 6 and 12 months of treatment,with astatistically significant difference(P<0.05).The treatment compliance of the rapid start group was 100.00%(32/32),and the virus inhibition rate was 93.75%(30/32),which were higher than 82.76%(24/29)and 68.97%(20/29)of the non rapid start group,the differences were statistically significant(P<0.05).The loss of follow-up rate was 0,which was lower than 17.24%(5/29)of the non rapid start group,the difference was statistically significant(P<0.05).Conclusion Rapid initiation(within 7 days of diagnosis)of HAART can maximize the adherence of HIV/AIDS patie

关 键 词：人类免疫缺陷病毒感染 艾滋病 快速启动高效抗反转录病毒治疗 病毒载量 依从性 预后 

分 类 号：R512.91[医药卫生—内科学]