IgA肾病研究的现状、问题与对策  

The research of IgA nephropathy:current status,problems and solutions

作　　者：李明[1] 司美君 蔡凤桃 余学清 LI Ming;SI Mie-jun;CAI Feng-tao;YU Xue-qing(Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China)

机构地区：[1]广东省人民医院,广东省医学科学院,广东广州510080

出　　处：《实用医院临床杂志》2024年第1期1-4,共4页Practical Journal of Clinical Medicine

摘　　要：IgA肾病是全球范围内最常见的原发性肾小球肾炎,是终末期肾脏病的主要病因之一。种族和地域差异及家族聚集性均提示遗传因素在IgA肾病的发病中起着一定的作用,同时免疫系统异常及糖基化缺失IgA1的产生也与IgA肾病的发病密切相关。研究IgA肾病的病因及发病机制对IgA肾病的诊断、治疗和预后有重要意义。本文对IgA肾病的遗传学研究、发病机制、微生物及代谢物组学及靶向药物等方面进行了相关的综述。IgA nephropathy is the most common primary glomerulonephritis worldwide and a leading cause of end-stage renal disease.Racial and regional differences and familial aggregation support the role of genetic factors in the pathogenesis of IgA nephropathy,while immune abnormalities and production of glycosylation-deficient IgA1 alsorelated to the pathogenesis of IgA nephropathy.Understanding the aetiology and pathogenesis of IgA nephropathy is important for diagnosing,treating and prognosing IgA nephropathy.The purpose of this review is to systematically summarize the recent advances in the genetic studies,the pathogenesis,the microbes and metabolites,and the targeted drugs in IgA nephropathy.

关 键 词：IGA肾病 糖基化缺失IgA1 遗传学研究 微生物及代谢物 靶向药物 

分 类 号：R692.6[医药卫生—泌尿科学]