新型食管细胞采集器-食管脱落细胞学检查在早期食管癌筛查中的应用研究  

Application of a novel examination of esophageal cell collector-esophageal exfoliative cytology in early esophageal cancer screening

作　　者：李彦蓉 帅平[2] 王洛伟 张涛 范文川 刘玉萍[2] LI Yan-rong;SHUAI Ping;WANG Luo-wei;ZHANG Tao;FAN Wen-chuan;LIU Yu-ping(University of Electronic Science and Technology of China,Chengdu 610054,China;Health Management Center,Sichuan Academy of Medical Sciences&Sichuan Provincial People′s Hospital,Chengdu 610072,China;Affiliated Shanghai Changhai Hospital of the Naval Medical University,Shanghai 200082,China;Nanchong Central Hospital,Nanchong 637000,China;Yanting County People′s Hospital,Yanting 621600,China)

机构地区：[1]电子科技大学医学院,四川成都610054 [2]四川省医学科学院·四川省人民医院健康管理中心,四川成都610072 [3]上海市海军军医大学附属长海医院,上海200082 [4]四川省南充市中心医院,四川南充637000 [5]四川省盐亭县人民医院,四川盐亭621600

出　　处：《实用医院临床杂志》2024年第1期109-115,共7页Practical Journal of Clinical Medicine

基　　金：四川省科技厅重点研发项目(编号:2021YFS0374);上海市科技创新行动计划医学专项项目(编号:21Y31900100)。

摘　　要：目的评价新型食管细胞采集器-食管脱落细胞学检查在早期食管癌筛查中的诊断效能。方法纳入四川省人民医院、南充市中心医院、盐亭县人民医院符合条件的体检人群,进行胃镜检查和新型食管细胞采集器检查,以胃镜-病理学结果为金标准,评价该检查在不同食管病变中的诊断效能;并绘制ROC曲线评价其对早期食管癌的筛查效能。结果新型食管细胞采集器-食管脱落细胞学检查对高级别上皮内瘤变筛查能力最好(灵敏度90.91%,特异度99.737%);对于早期食管癌的筛查ROC曲线下面积为0.946(0.899~0.994),灵敏度为84.20%,特异度为96.20%,约登指数0.804。结论新型食管细胞采集器-食管脱落细胞学检查对各食管病变筛查的特异度超过90%,适合成为早期食管癌的筛查手段。Objective To evaluate the diagnostic efficacy of a novel test of esophageal cell collector-esophageal exfoliative cytology in early screening of esophageal cancer.Methods This study included eligible medical examination population in Sichuan Provincial People's Hospital,Nanchong Central Hospital,and Yanting County People's Hospital.They were subjected to gastroscopy and new esophageal cell collection.Gastroscopy-pathology results were taken as the gold standard,the diagnostic efficacy of this test in different esophageal lesions was evaluated.ROC curves analysis was performed to evaluate its screening efficacy for early esophageal cancer.ResultsThe novel test of esophageal cell collector-esophageal exfoliative cytology had the best screening ability for high-grade intraepithelial neoplasia with 90.91%of sensitivity and 99.737%of specificity.For the screening of early esophageal cancer,the area under the R0C curve(AUC)was 0.946(95%CI=0.899~0.994).The sensitivity was 84.20%.The specificity was 96.20%and the Yordon index was 0.804.Conclusions The novel test of esophageal cell collector-esophageal exfoliative cytology has a specificity of over 90%for the screening of each esophageal lesion.It is suitable as a screening tool for early esophageal cancer.

关 键 词：早期食管癌 食管癌癌前病变 新型食管细胞采集器 食管脱落细胞学检查 诊断效能 

分 类 号：R735.1[医药卫生—肿瘤]