阿托西班治疗孕24周前晚期先兆流产的效果  

The effect of atoxiban in the treatment of threatened miscarriage in late stages of pregnancy before 24 weeks

作　　者：朱吉 谢崟[2] ZHU Ji;XIE Yin(Department of Pharmacy,Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University,Changzhou,Jiangsu,213023,China;Department of Pharmacy,Changzhou First People's Hospital,Changzhou,Jiangsu,213000,China)

机构地区：[1]南京医科大学附属常州妇幼保健院药事科,江苏常州213023 [2]常州市第一人民医院药剂科,江苏常州213000

出　　处：《当代医学》2023年第32期42-45,共4页Contemporary Medicine

基　　金：常州市科技局医院药学科研专项指导性项目(2016411)。

摘　　要：目的探讨阿托西班治疗孕24周前晚期先兆流产的效果。方法选取2017年1月至2020年12月南京医科大学附属常州妇幼保健院收治的80例孕24周前晚期先兆流产患者作为研究对象,按照随机数字表法分为对照组与研究组,每组40例。对照组采用临床常规治疗,研究组通过构建阿托西班药物利用评价(DUE)治疗。比较两组临床疗效、症状改善时间、母体耐受情况、继续妊娠率及药物不良反应发生情况。结果治疗48 h、7 d后,研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组阴道止血时间、腹痛缓解时间、宫缩停止时间均短于对照组,差异有统计学意义(P<0.05);研究组母体耐受优良率、1个月内继续妊娠率均高于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论通过构建阿托西班DUE治疗孕24周前晚期先兆流产对促进患者症状、体征恢复,降低流产风险及药物不良反应发生风险均有积极意义,值得临床推广应用。Objective To explore the effect of atoxiban in the treatment of threatened miscarriage in the late stages of pregnancy before 24 weeks.Methods 80 patients with threatened miscarriage in the late 24 weeks of pregnancy admitted to Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University from January 2017 to December 2020 were selected as the study subjects,and they were randomly divided into the control group and the study group according to the random number table method,with 40 cases in each group.The control group received routine clinical treatment,while the study group received treatment by constructing a drug utilization evaluation(DUE)for atoxiban,the clinical efficacy,symptom improvement time,maternal tolerance,continued pregnancy rate,and incidence of adverse drug reactions were compared between two groups.Results After 48 h and 7 d treatment,the total effective rate in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05);the vaginal bleeding cessation time,abdominal pain relief time,and uterine contraction cessation time in the study group were shorter than those in the control group,the differences were statistically significant(P<0.05);the excellent maternal tolerance rate and the rate of continuing pregnancy within one month in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05);the incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The construction of atoxiban DUE for the treatment of threatened miscarriage in the early and late stages of pregnancy before 24 weeks has a positive significance in promoting the recovery of symptoms and signs,reducing the risk of miscarriage and adverse drug reactions,and is worthy of clinical promotion and application.

关 键 词：先兆流产 阿托西班 药物利用标准 

分 类 号：R714.21[医药卫生—妇产科学]