变应性鼻炎的免疫学发病机制——从经典免疫失衡到辅助性T细胞2/调节性T细胞免疫失衡的转变  

Immunological pathogenesis of allergic rhinitis—transition from classical immune imbalance to Th2/Treg immune imbalance

作　　者：邱梦婷 戴启刚[1] QIU Mengting;DAI Qigang(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu,210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《当代医学》2023年第32期174-178,共5页Contemporary Medicine

基　　金：江苏省中医药局科技项目(YB2017001)。

摘　　要：变应性鼻炎是常见的鼻黏膜慢性炎症反应性疾病,以喷嚏、鼻痒、鼻塞、流涕为特征性症状,其发病率随年龄增长而逐渐升高,严重影响人们的日常生活。该病发病机制十分复杂,目前主要认为辅助性T细胞(Th)1/Th2(Th1/Th2)免疫失衡并向Th2免疫反应转化最为经典,近年来也提出了调节性T细胞(Treg)、Th17等细胞反应的参与。本文主要对变应性鼻炎的免疫学发病机制进行综述。Allergic rhinitis is a common chronic inflammatory disease of nasal mucosa,with sneezing,nasal itching,nasal congestion and runny nose as the characteristic symptoms.And it gradually increases with the growth of age,which seriously affects people's daily life.However,its pathogenesis is also complex,At present,it's mainly believed that the imbalance of T helper cell(Th)1/Th 2(Th1/Th2)immune response and its transformation to Th2 immune response are the most classic.In recent years,the involvement of cellular responses such as T regulatory cell(Treg)and Th17 has also been propesed.This article mainly reviews the immunological pathogenesis of allergic rhinitis.

关 键 词：变应性 发病机制 免疫失衡 辅助性T细胞1/辅助性T细胞2 辅助性T细胞17/调节性T细胞 

分 类 号：R392[医药卫生—免疫学]