Impact of frailty on outcomes of elderly patients undergoing percutaneous coronary intervention: A systematic review and metaanalysis  

作　　者：Shi-Shi Wang Wang-Hao Liu 

机构地区：[1]Department of Emergency Medicine,Huzhou Third Municipal Hospital,The Affiliated Hospital of Huzhou University,Huzhou 313000,Zhejiang Province,China [2]Department of Geriatrics,Huzhou Third Municipal Hospital,the Affiliated Hospital of Huzhou University,Huzhou 313000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第1期107-118,共12页世界临床病例杂志

摘　　要：BACKGROUND Frailty is a common condition in elderly patients who receive percutaneous coronary intervention(PCI).However,how frailty affects clinical outcomes in this group is unclear.AIM To assess the link between frailty and the outcomes,such as in-hospital complic-ations,post-procedural complications,and mortality,in elderly patients post-PCI.METHODS The PubMed/MEDLINE,EMBASE,Cochrane Library,and Web of Science databases were screened for publications up to August 2023.The primary outcomes assessed were in-hospital and all-cause mortality,major adverse cardiovascular events(MACEs),and major bleeding.The Newcastle-Ottawa Scale was used for quality assessment.RESULTS Twenty-one studies with 739693 elderly patients undergoing PCI were included.Frailty was consistently associated with adverse outcomes.Frail patients had significantly higher risks of in-hospital mortality[risk ratio:3.45,95%confidence interval(95%CI):1.90-6.25],all-cause mortality[hazard ratio(HR):2.08,95%CI:1.78-2.43],MACEs(HR:2.92,95%CI:1.85-4.60),and major bleeding(HR:4.60,95%CI:2.89-7.32)compared to non-frail patients.CONCLUSION Frailty is a pivotal determinant in the prediction of risk of mortality,development of MACEs,and major bleeding in elderly individuals undergoing percutaneous coronary intervention.

关 键 词：FRAILTY ELDERLY Percutaneous coronary intervention Systematic review META-ANALYSIS 

分 类 号：R541.6[医药卫生—心血管疾病]