Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients  

作　　者：Dharmsheel Shrivastav Desh Deepak Singh Rashid Mir Pratishtha Mehra Vimal Mehta Pradeep Kumar Dabla 

机构地区：[1]Amity Institute of Biotechnology,Amity University,Jaipur 303002,Rajasthan,India [2]Department of Biochemistry,Govind Ballabh Pant Institute of Postgraduate Medical Education and Research,Delhi 110002,India [3]Department of Medical Lab Technology,Faculty of Applied Medical Sciences,University of Tabuk,Tabuk 71491,India [4]Department of Cardiology,Govind Ballabh Pant Institute of Postgraduate Medical Education and Research,Delhi 110002,India

出　　处：《World Journal of Diabetes》2023年第12期1754-1765,共12页世界糖尿病杂志（英文版）（电子版）

摘　　要：BACKGROUND Coronary artery disease(CAD)is a major cause of death worldwide,and India contributes to about one-fifth of total CAD deaths.The development of CAD has been linked to the accumulation of Nε-carboxymethyl-lysine(CML)in heart muscle,which correlates with fibrosis.AIM To assess the impact of CML and inflammatory markers on the biochemical and cardiovascular characteristics of CAD patients with and without diabetes.METHODS We enrolled 200 consecutive CAD patients who were undergoing coronary angiography and categorized them into two groups based on their serum glycosylated hemoglobin(HbA1c)levels(group I:HbA1c≥6.5;group II:HbA1c<6.5).We analyzed the levels of lipoproteins,plasma HbA1c levels,CML,interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α),and nitric oxide.RESULTS Group I (81 males and 19 females) patients had a mean age of 54.2 ± 10.2 years, with a mean diabetes duration of4.9 ± 2.2 years. Group II (89 males and 11 females) patients had a mean age of 53.2 ± 10.3 years. Group I had moresevere CAD, with a higher percentage of patients with single vessel disease and greater stenosis severity in the leftanterior descending coronary artery compared to group II. Group I also exhibited a larger left atrium diameter.Group I patients exhibited significantly higher levels of CML, TNF-α, and IL-6 and lower levels of nitric oxide ascompared with group II patients. Additionally, CML showed a significant positive correlation with IL-6 (r = 0.596,P = 0.001) and TNF-α (r = 0.337, P = 0.001) and a negative correlation with nitric oxide (r=-4.16, P = 0.001). Oddsratio analysis revealed that patients with CML in the third quartile (264.43-364.31 ng/mL) were significantlyassociated with diabetic CAD at unadjusted and adjusted levels with covariates.

关 键 词：Coronary artery disease Diabetes Nε-carboxymethyl-lysine Inflammatory markers INTERLEUKIN-6 Tumor necrosis factor alpha Nitric oxide 

分 类 号：R587.1[医药卫生—内分泌]