Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial  

作　　者：Sebastian Hoerder Isabel Valentina Habermann Katrin Hahn Gesa Meyer-Hamme Miriam Ortiz Weronika Grabowska Stephanie Roll Stefan N.Willich Sven Schroeder Benno Brinkhaus Joanna Dietzel 

机构地区：[1]Institute of Social Medicine,Epidemiology and Health Economics,CharitéUniversitätsmedizin,Berlin 10117,Germany [2]Department of Neurology,CharitéUniversitätsmedizin,Charitéplatz 1,Berlin 10117,Germany [3]HanseMerkur Center of Traditional Chinese Medicine at University Hospital Eppendorff,Martinistr 52,Hamburg 20246,Germany

出　　处：《World Journal of Diabetes》2023年第12期1813-1823,共11页世界糖尿病杂志（英文版）（电子版）

摘　　要：BACKGROUND Diabetic peripheral neuropathy(DPN)is a common complication of diabetes mellitus and can lead to serious complications.Therapeutic strategies for pain control are available but there are few approaches that influence neurological deficits such as numbness.AIM To investigate the effectiveness of acupuncture on improving neurological deficits in patients suffering from type 2 DPN.METHODS The acupuncture in DPN(ACUDPN)study was a two-armed,randomized,controlled,parallel group,open,multicenter clinical trial.Patients were randomized in a 1:1 ratio into two groups:The acupuncture group received 12 acupuncture treatments over 8 wk,and the control group was on a waiting list during the first 16 wk,before it received the same treatment as the other group.Both groups received routine care.Outcome parameters were evaluated after 8,16 and 24 wk and included neurological scores,such as an 11-point numeric rating scale(NRS)11 for hypesthesia,neuropathic pain symptom inventory(NPSI),neuropathy deficit score(NDS),neuropathy symptom score(NSS);nerve conduction studies(NCS)were assessed with a handheld point-of-care device.RESULTSSixty-two participants were included.The NRS for numbness showed a difference of 2.3(P<0.001)in favor of theacupuncture group,the effect persisted until week 16 with a difference of 2.2(P<0.001)between groups and 1.8points at week 24 compared to baseline.The NPSI was improved in the acupuncture group by 12.6 points(P<0.001)at week 8,the NSS score at week 8 with a difference of 1.3(P<0.001);the NDS and the TNSc score improvedfor the acupuncture group in week 8,with a difference of 2.0 points(P<0.001)compared to the control group.Effects were persistent in week 16 with a difference of 1.8 points(P<0.05).The NCS showed no meaningfulchanges.In both groups only minor side effects were reported.CONCLUSION Study results suggest that acupuncture may be beneficial in type 2 diabetic DPN and seems to lead to a reductionin neurological deficits.No serious adverse events were recorded and the adherence to

关 键 词：Diabetic peripheral neuropathy NUMBNESS Nerve conduction study ACUPUNCTURE 

分 类 号：R245[医药卫生—针灸推拿学] R587.1[医药卫生—中医临床基础]