Predictive value of bilirubin and serum γ-glutamyltranspeptidase levels in type-2 diabetes mellitus patients with acute coronary syndrome  

作　　者：Jie Chen Wan-Chao Zhang Xiao-Qiang Tang Ruo-Han Yin Tao Wang Xiao-Yu Wei Chang-Jie Pan 

机构地区：[1]Radiology Department,The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213164,Jiangsu Province,China [2]Radiology Department,The People’s Hospital of WuQia County,Wuqia 845450,Xinjiang Uygur Autonomous Region,China

出　　处：《World Journal of Diabetes》2024年第1期34-42,共9页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by Science and Technology Major Project of Changzhou Science and Technology Bureau,No.CE20205047;Natural Science Foundation of Xinjiang Uygur Autonomo us Region,No.ZD202220;Changzhou A major scientific research project of the Municipal Health Commission,No.2022D01F52.

摘　　要：BACKGROUND Cardiovascular disease is a major complication of diabetes mellitus(DM).Type-2 DM(T2DM)is associated with an increased risk of cardiovascular events and mortality,while serum biomarkers may facilitate the prediction of these outcomes.Early differential diagnosis of T2DM complicated with acute coronary syndrome(ACS)plays an important role in controlling disease progression and improving safety.AIM To investigate the correlation of serum bilirubin andγ-glutamyltranspeptidase(γ-GGT)with major adverse cardiovascular events(MACEs)in T2DM patients with ACS.METHODS The clinical data of inpatients from January 2022 to December 2022 were analyzed retrospectively.According to different conditions,they were divided into the T2DM complicated with ACS group(T2DM+ACS,n=96),simple T2DM group(T2DM,n=85),and simple ACS group(ACS,n=90).The clinical data and laboratory indices were compared among the three groups,and the correlations of serum total bilirubin(TBIL)levels and serumγ-GGT levels with other indices were discussed.T2DM+ACS patients received a 90-day follow-up after discharge and were divided into event(n=15)and nonevent(n=81)groups according to the occurrence of MACEs;Univariate and multivariate analyses were further used to screen the independent influencing factors of MACEs in patients.RESULTS The T2DM+ACS group showed higherγ-GGT,total cholesterol,low-density lipoprotein cholesterol(LDL-C)and glycosylated hemoglobin(HbA1c)and lower TBIL and high-density lipoprotein cholesterol levels than the T2DM and ACS groups(P<0.05).Based on univariate analysis,the event and nonevent groups were significantly different in age(t=3.3612,P=0.0011),TBIL level(t=3.0742,P=0.0028),γ-GGT level(t=2.6887,P=0.0085),LDL-C level(t=2.0816,P=0.0401),HbA1c level(t=2.7862,P=0.0065)and left ventricular ejection fraction(LEVF)levels(t=3.2047,P=0.0018).Multivariate logistic regression analysis further identified that TBIL level and LEVF level were protective factor for MACEs,and age andγ-GGT level were risk factors(P<0.05).CONCLUSION

关 键 词：Acute coronary syndrome Type-2 diabetes mellitus Total bilirubin Major adverse cardiovascular events 

分 类 号：R587.2[医药卫生—内分泌] R541.4[医药卫生—内科学]