Investigating the relationship between intracranial atherosclerotic plaque remodelling and diabetes using high-resolution vessel wall imaging  

作　　者：Yong-Qian Mo Hai-Yu Luo Han-Wen Zhang Yu-Feng Liu Kan Deng Xiao-Lei Liu Biao Huang Fan Lin 

机构地区：[1]Department of Radiology,Peking University Shenzhen Hospital,Shenzhen 518000,Guangdong Province,China [2]Department of Ultrasound,Peking University Shenzhen Hospital,Shenzhen 518000,Guangdong Province,China [3]The Second School of Clinical Medicine,Southern Medical University,Guangzhou 510282,Guangdong Province,China [4]Department of Radiology,The First Affiliated Hospital of Shenzhen University,Health Science Center,Shenzhen Second People’s Hospital,Shenzhen 518036,Guangdong Province,China [5]Research Department,Philips Healthcare,Guangzhou 518000,Guangdong Province,China [6]Department of Radiology,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510000,Guangdong Province,China

出　　处：《World Journal of Diabetes》2024年第1期72-80,共9页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by National Natural Science Foundation of China,No.82071871;Guangdong Basic and Applied Basic Research Foundation,No.2021A1515220131;Guangdong Medical Science and Technology Research Fund Project,No.2022111520491834;Clinical Research Project of Shenzhen Second People's Hospital,No.20223357022。

摘　　要：BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque formation.This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imaging(HR-VWI).AIM To investigate the factors of intracranial atherosclerotic remodelling patterns and the relationship between intracranial atherosclerotic remodelling and diabetes mellitus using HR-VWI.METHODS Ninety-four patients diagnosed with middle cerebral artery or basilar artery INTRODUCTION Intracranial atherosclerotic disease is one of the main causes of ischaemic stroke in the world,accounting for approx-imately 10%of transient ischaemic attacks and 30%-50%of ischaemic strokes[1].It is the most common factor among Asian people[2].The adaptive changes in the structure and function of blood vessels that can adapt to changes in the internal and external environment are called vascular remodelling,which is a common and important pathological mechanism in atherosclerotic diseases,and the remodelling mode of atherosclerotic plaques is closely related to the occurrence of stroke.Positive remodelling(PR)is an outwards compensatory remodelling where the arterial wall grows outwards in an attempt to maintain a constant lumen diameter.For a long time,it was believed that the degree of stenosis can accurately reflect the risk of ischaemic stroke[3-5].Previous studies have revealed that lesions without significant luminal stenosis can also lead to acute events[6,7],as summarized in a recent meta-analysis study in which approximately 50%of acute/subacute ischaemic events were due to this type of lesion[6].Research[8,9]has pointed out that the PR of plaques is more dangerous and more likely to cause acute ischaemic stroke.Previous studies[10-13]have found that there are specific vascular remodelling phenomena in the coronary and carotid arteries of diabetic patients.However,due to the deep location and small lumen of intracranial arteries and limitations of imaging techniques,the relationship between intra

关 键 词：High-resolution vessel wall imaging Intracranial atherosclerosis Vascular remodelling Magnetic resonance imaging 

分 类 号：R543.5[医药卫生—心血管疾病] R587.2[医药卫生—内科学]