Impact of hepatectomy and postoperative adjuvant transarterial chemoembolization on serum tumor markers and prognosis in intermediate-stage hepatocellular carcinoma  

作　　者：Yi-Di Hu Hui Zhang Wei Tan Zhuo-Kai Li 

机构地区：[1]Department of Surgery,Wenzhou TCM Hospital of Zhejiang Chinese Medical University,Wenzhou 325000,Zhejiang Province,China [2]Department of Hepatobiliary and Pancreatic Surgery,Lishui Municipal Central Hospital,Lishui 323000,Zhejiang Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2023年第12期2820-2830,共11页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Primary hepatocellular carcinoma(HCC)is a common malignant tumour,and its early symptoms are often not obvious,resulting in many patients experiencing middle-to late-stage disease at the time of diagnosis.The optimal time for surgery is often missed for these patients,and those who do undergo surgery have unsatisfactory long-term outcomes and a high recurrence rate within five years.Therefore,postoperative follow-up treatments,such as transhepatic arterial chemoembolization(TACE),have become critical to improving survival and reducing recurrence rates.AIM To validate the prophylactic role of TACE after hepatic resection and to assess its impact on patient prognosis.METHODS This study investigated the efficacy of TACE in patients with intermediate-stage HCC after hepatectomy.When the post-treatment results of the observation group and the control group were compared,it was found that the inclusion of TACE significantly improved the clinical efficacy,reduced the levels of tumour markers and did not aggravate the damage to liver function.Thus,this may be an effective and comprehensive treatment strategy for patients with intermediate-stage HCC that helps to improve their quality of life and survival time.RESULTS When the baseline data were analysed,no statistical differences were found between the two groups in terms of gender,age,hepatitis B virus,cirrhosis,Child-Pugh grading,number of tumours,maximum tumour diameter and degree of tumour differentiation.The assessment of clinical efficacy showed that the post-treatment overall remission rate of the observation group was significantly higher than that of the control group.In terms of changes in tumour markers,the alpha-fetoprotein and carcinoembryonic antigen levels in the patients in the observation group decreased more significantly after treatment compared with those in the control group.When post-treatment changes in liver function indicators were analysed,no statistical differences were found in the total bilirubin,alanine aminotransferase and aspart

关 键 词：Primary liver cancer Transhepatic arterial chemoembolization Treatment outcome PROGNOSIS Tumour markers Liver function indices 

分 类 号：R735.7[医药卫生—肿瘤]