The correlation of spot urinary protein-to-creatinine ratio with 24-h urinary protein excretion in various glomerulopathies  

作　　者：Amber Raza Syed Haider Nawaz Rahma Rashid Ejaz Ahmed Muhammed Mubarak 

机构地区：[1]Department of Nephrology,Sindh Institute of Urology and Transplantation,Sindh,Karachi 74200,Pakistan [2]Department of Pathology,Sindh Institute of Urology and Transplantation,Sindh,Karachi 74200,Pakistan

出　　处：《World Journal of Nephrology》2023年第5期159-167,共9页世界肾病学杂志（英文版）

摘　　要：BACKGROUND Proteinuria is an important and well-known biomarker of many forms of kidney injury.Its quantitation is of particular importance in the diagnosis and management of glomerular diseases.Its quantification can be done by several methods.Among these,the measurement of 24-h urinary protein excretion is the gold standard method.However,it is cumbersome,time-consuming,and inconvenient for patients and is not completely foolproof.Many alternative methods have been tested over time albeit with conflicting results.Among the latter,the measurement of urine protein-to-creatinine ratio(uPCR)in singlevoided urinary samples is widely used.The majority of studies found a good correlation between uPCR in single urine samples with 24-h urinary protein estimation,whereas others did not.AIM To investigate the correlation of spot uPCR with 24-h urinary protein estimation in patients suffering from different forms of glomerulopathies at a single largevolume nephrological center in Pakistan.METHODS This cross-sectional,observational study was conducted at the Department of Nephrology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan from September 2017 to March 2018.All newly presenting adult patients with proteinuria who were being investigated for suspected glomerulonephritis and persistent proteinuria with ages between 18 to 60 years were enrolled.All patients were given detailed advice regarding 24-h urine collection starting at 7:00 AM for total protein and creatinine excretion estimations.A spot urine sample was collected the next day at the time of submission of a 24-h urine sample for measuring uPCR along with a blood sample.The data of patients were collected in a proforma.SPSS version 20.0 was used for statistical analysis.RESULTS A total of 157 patients were included.Their mean age was 30.45±12.11 years.There were 94(59.8%)males and 63(40.2%)females.The mean 24-h urinary protein excretion was 3192.78±1959.79 mg and the mean spot uPCR was 3.16±1.52 in all patients.A weak but significant correlation

关 键 词：Glomerulopathies 24-h proteinuria Spot urinary protein-to-creatinine ratio Correlation PROTEINURIA Agreement 

分 类 号：R69[医药卫生—泌尿科学]