耳穴压丸联合耳穴揿针疗法治疗儿童青少年近视的多中心随机对照研究  

A Multicenter Randomized Controlled Study of Auricular Pressure Pellet Combined with Auricular Acupressure Therapy on Myopia in Children and Adolescents

作　　者：侯昕玥 王健全 曹珂儿 李书娇 孙宏睿 亢泽峰[1] 李武军 褚利群 邢凯 王养忠[7] 刘军[8] 刘松 陈水龄 高瑞 张丛青 张岚[1] 杨剑英[1] 宿蕾艳[1] 张莎莎 霍蕊莉[2] 杨永升[1] 宋曼 HOU Xinyue;WANG Jianquan;CAO Ke´er;LI Shujiao;SUN Hongrui;KANG Zefeng;LI Wujun;CHU Liqun;XING Kai;WANG Yangzhong;LIU Jun;LIU Song;CHEN Shuiling;GAO Rui;ZHANG Congqing;ZHANG Lan;YANG Jianying;SU Leiyan;ZHANG Shasha;HUO Ruili;YANG Yongsheng;SONG Man(Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,北京100040 [2]中国中医科学院,北京100700 [3]陕西省西安市中医医院,西安710021 [4]陕西省榆林市中医医院,榆林719099 [5]中国中医科学院西苑医院,北京100091 [6]北京市昌平区中医医院,北京102299 [7]北京中医药大学东直门医院,北京100700 [8]深圳市眼科医院,深圳518040 [9]福建中医药大学附属福州中医院,福州350003

出　　处：《中国中医眼科杂志》2024年第1期9-15,共7页China Journal of Chinese Ophthalmology

基　　金：国家中医药管理局中医药古籍文献和特色技术传承专项(GZY-KJS-2020-081);中医药传承与创新“百千万”人才工程(岐黄学者);福建省第三批柔性引进医疗卫生高层次人才团队项目。

摘　　要：目的 观察耳穴压丸联合耳穴揿针疗法对儿童青少年近视的临床疗效和安全性。方法 纳入2021年7月—2022年10月中国中医科学院眼科医院等6家医院诊治的低度近视和近视前期患儿156例(156只眼),随机分为试验组和对照组,每组78例(78只眼)。对照组予健康宣教+足矫配镜(近视前期患儿只予健康宣教);试验组在对照组的基础上联合耳穴压丸+耳穴揿针治疗。分别于治疗前、治疗后6周、12周和24周检测受试者的裸眼远视力(UCDVA)、等效球镜度(SE)、眼轴(AL)和全身症状评分,并进行统计分析。结果 2组患儿治疗前的UCDVA、SE、AL和全身症状评分比较,差异均无统计学意义(P>0.05)。(1)UCDVA:治疗前后比较,试验组各时间节点UCDVA较治疗前比较,差异均无统计学意义(P>0.05)。对照组治疗后12周和24周UCDVA均较治疗前降低,差异均有与统计学意义(Z12_(周)=3.495,Z24_(周)=3.950,均P=0.000)。2组间比较,试验组治疗后6周、12周和24周UCDVA均高于对照组,差异均有统计学意义(Z6_(周)=2.655,P=0.008;Z12_(周)=3.441,P=0.001;Z24_(周)=2.933,P=0.003)。(2)SE:治疗前后比较,试验组治疗后12周和24周SE均较治疗前升高,差异均有统计学意义(t12_(周)=2.349,P=0.020;t24_(周)=3.643,P=0.000)。对照组治疗后各时间节点SE均较治疗前升高,差异均有统计学意义(t6_(周)=5.861、t12_(周)=7.640、t24_(周)=9.845,均P=0.000)。2组间比较,试验组治疗后6周、12周和24周SE均低于对照组,差异均有统计学意义(t6_(周)=3.392,P=0.001;t12_(周)=3.468,P=0.001;t24_(周)=3.968,P=0.000)。2组治疗后24周与治疗前的SE差值比较,差异有统计学意义(t=4.529,P=0.000)。(3)AL:2组AL治疗后各时间节点与治疗前的比较及组间比较,差异均无统计学意义(P>0.05)。2组间差值比较,试验组治疗后24周与治疗前的AL差值低于对照组,差异有统计学意义(t=2.035,P=0.044)。(4)全身症状评分:治疗前后比较,试验组治疗后6周、12周�OBJECTIVE To observe the clinical effectiveness and safety of auricular pellet compression combined with auricular press needle therapy in treating myopia in children and adolescents.METHODS A total of 156 cases(156 eyes)of mild myopia and pre-myopia children treated in six hospitals,including the Eye Hospital,China Academy of Chinese Medical Sciences,from July 2021 to October 2022 were randomly divided into experimental and control groups,each comprising 78 cases(78 eyes).The control group received health education and orthokeratology lenses(health education only for pre-myopia children);The experimental group received combined treatment of auricular pellet compression and auricular press needle therapy based on the control group.Uncorrected distance visual acuity(UCDVA),spherical equivalent(SE),axial length(AL),and systemic symptom scores were measured before treatment,at six weeks(6 w),12 weeks(12 w),and 24 weeks(24 w)post-treatment,followed by statistical analysis.RESULTS There were no statistically significant differences in UCDVA,SE,AL,and systemic symptom scores between the two groups before treatment(P>0.05).(1)UCDVA:There were no statistically significant differences in UCDVA compared to pre-treatment at each time point in the experimental group(P>0.05).The UCDVA of the control group decreased significantly at 12 weeks and 24 weeks posttreatment compared to pre-treatment(Z_(12w)=3.495,Z_(24w)=3.950,all P=0.000).Comparing between the two groups,the UCDVA at 6,12 and 24 weeks post-treatment were higher in the experimental group than in the control group,showing statistical significance(Z_(6w)=2.655,P=0.08;Z_(12w)=3.441,P=0.001;Z_(24w)=2.933,P=0.003).(2)SE:Post-treatment comparisons showed that SE significantly increased at 12 and 24 weeks in the experimental group compared to pre-treatment(t_(12w)=2.349,P=0.020;t_(24w)=3.643,P=0.000).The control group also had a significant increase in SE at each time point posttreatment compared to pre-treatment(t_(6w)=5.861,t_(12w)=7.640,t_(24w)=9.845,all P=0.000).Compar

关 键 词：近视 耳穴疗法 揿针 多中心、随机对照研究 儿童青少年 

分 类 号：R246.82[医药卫生—针灸推拿学]