二甲双胍治疗对T2DM患者体内8-iso-PGF_(2α),11-dehydro-TXB_(2)水平的影响  

Effect of Metformin Treatment on the Levels of 8-iso-PGF_(2α)and 11-dehydro-TXB_(2)in T2DM Patients

作　　者：李进冬 高一 杨淑芳 徐震[1] 薛露 季晓慧 LI Jin-dong;GAO Yi;YANG Shu-fang;XU Zhen;XUE Lu;JI Xiao-hui(The Affiliated Taizhou People's Hospital of Nanjing Medical University,Taizhou Jiangsu 225300,China)

机构地区：[1]南京医科大学附属泰州人民医院,江苏泰州225300

出　　处：《泰州职业技术学院学报》2023年第6期62-65,72,共5页Journal of Taizhou Polytechnic College

基　　金：南京医科大学附属泰州人民医院2018年度院级课题(ZL201831,课题负责人:李进冬);江苏省研究型医院学会精益化用药-石药专项科研基金项目(JY202229,项目主持人:李进冬)。

摘　　要：目的观察二甲双胍治疗对2型糖尿病患者体内8-iso-PGF_(2α)与11-dehydro-TXB_(2)水平的影响,探讨其在糖尿病血管病变中的作用。方法收集2019年1月至12月就诊于泰州市人民医院并诊断为T2DM的患者30例作为观察组(HG),将服用二甲双胍(0.5g,qd)至少2个月的T2DM患者30例作为二甲双胍片治疗组(MET),同期来自体检中心的健康人群30例作为健康对照组(NG)。收集各组空腹血糖(FPG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、肌酐(CREA)、尿素氮(BUN)等数据;酶联免疫吸附法检测8-iso-PGF_(2α)和11-dehydro-TXB_(2)水平。结果与NG组相比,HG组FPG、HbA1c、8-iso-PGF_(2α)、11-dehydro-TXB_(2)水平明显上升(P均<0.01);与HG组相比,MET组FPG、HbA1c、8-iso-PGF_(2α)、11-dehydro-TXB_(2)水平明显下降(P<0.01或P<0.05)。结论二甲双胍可能通过降低糖尿病患者体内8-iso-PGF_(2α)、11-dehydro-TXB_(2)水平,从而达到心血管保护作用。Objective To observe the effect of metformin treatment on the levels of 8-iso-PGF_(2α)and 11-dehy⁃dro-TXB_(2)in patients with type 2 diabetes,and to explore its role in diabetic vasculopathy.Methods 30 patients diagnosed with type 2 diabetes in Taizhou People's Hospital from January to December 2019 were collected as group HG.30 cases T2DM who would take metformin(0.5g qd)for at least 2 months were included in the ex⁃perimental group MET,and 30 healthy people from the physical examination center were in group NG.Pa⁃tients'fasting blood glucose(FPG),glycated hemoglobin(HbA1c),triglycerides(TG),total cholesterol(TC),as⁃partate aminotransferase(AST),alanine aminotransferase(ALT),creatinine(CREA),urea nitrogen(BUN)other data were collected;8-iso-PGF_(2α)and 11-dehydro-TXB_(2)levels were detected by ELISA.Results Compared with the NG group,the levels of FPG,HbA1c,8-iso-PGF_(2α),11-dehydro-TXB_(2)in the HG group increased significantly(P<0.01).Compared with the HG group,the FPG,HbA1c,8-iso-PGF_(2α),11-dehydro-TXB_(2)lev⁃els dropped significantly(P<0.01or P<0.05).Conclusion Metformin can achieve cardiovascular protection by re⁃ducing the levels of 8-iso-PGF_(2α)and 11-dehydro-TXB_(2)in diabetic patients.

关 键 词：二甲双胍 2型糖尿病 血管病变 8-iso-PGF_(2α) 11-dehydro-TXB_(2) 

分 类 号：R587.1[医药卫生—内分泌]