长链非编码RNA和环状RNA在后肢缺血中的研究进展  

Research progress of lncRNA and circRNA in hind limb ischemia

作　　者：丁凤枝(综述) 王海华 孙丽 丁彩云(审校) DING Fengzhi;WANG Haihua;SUN Li;DING Caiyun(Department of Physiology,School of Basic Medical Sciences,Wannan Medical College,Wuhu 241000,Anhui,China)

机构地区：[1]皖南医学院基础医学院生理学教研室,芜湖241000

出　　处：《医学研究与战创伤救治》2023年第9期995-999,共5页Journal of Medical Research & Combat Trauma Care

基　　金：安徽省教育厅自然科学研究重点项目(2022AH051243,2023AH051766);皖南医学院博士科研启动基金(WYRCQD2023008,WYRCQD2021001)。

摘　　要：随着预期寿命的不断延长,人群中后肢缺血的患病率可能会进一步增加。血流量的减少导致缺氧和营养素的缺乏,从而引起后肢缺血后骨骼肌坏死。目前,尚无有效的药物干预来治疗后肢缺血,尤其是对于老年人和糖尿病患者来说,探究新的后肢缺血的治疗方法刻不容缓。越来越多的证据表明,长链非编码RNA(lncRNA)和环状RNA(circRNA)参与调控后肢缺血的修复。文章主要就lncRNA和circRNA在后肢缺血中的研究进展进行综述。As life expectancy continues to increase,the prevalence of hind limb ischemia(HLI)in the population is likely to increase further.Reduced blood flow results in hypoxia and nutrient deficiencies,leading to skeletal muscle necrosis after HLI.Currently,there is no effective pharmacological intervention to treat HLI,especially for the elderly and diabetic patients.It is urgent to explore new treatment methods for HLI.Increasing evidence shows that long noncoding RNA(lncRNA)and circular RNA(circRNA)are involved in regulating the repair of HLI.This article mainly reviews the research progress of lncRNA and circRNA in hind limb ischemia.

关 键 词：长链非编码RNA 环状RNA 后肢缺血 内皮细胞 血管新生 

分 类 号：R331.3[医药卫生—人体生理学]