维吾尔族青少年颈椎骨龄与生物年龄的相关参数分析  

Analysis of correlation parameters between cervical spine bone age and biological age in Uygur adolescents

作　　者：杨莉 赵玺 范雅儒 Yang Li;Zhao Xi;Fan Yaru(Department of Orthodontics,Urumqi Stomatological Hospital,Urumqi 830002,Xinjiang,China)

机构地区：[1]乌鲁木齐市口腔医院正畸科,新疆乌鲁木齐830002

出　　处：《中国法医学杂志》2023年第6期664-669,共6页Chinese Journal of Forensic Medicine

基　　金：乌鲁木齐市卫生健康委科技计划项目—乌鲁木齐市维吾尔族青少年颈椎骨龄与实际年龄的相关性研究(202021)。

摘　　要：目的探讨乌鲁木齐市维吾尔族青少年颈椎骨龄常用参数,并推导乌鲁木齐市维吾尔族青少年颈椎骨龄的回归方程,评估其应用于推断生物年龄的意义。方法第一部分:选取2017年1月~2020年10月就诊于乌鲁木齐市口腔医院正畸科的7~16岁的维吾尔族青少年患者300例(男150例,女150例)。对第三、第四颈椎进行定点测量(AH3、PH3、AP3、H3、AH4、PH4、AP4、H4),并获得能够代表颈椎锥体形态变化的相应比值(AH3/AP3、AH3/H3、H3/AP3、H3/PH3、PH3/AP3、AH4/AP4、AH4/H4、H4/AP4、H4/PH4、PH4/AP4),将比值数据分别带入Mito提出的女性及男性青少年颈椎骨龄的回归方程,将所得预估年龄与生物年龄进行配对分析,评估Mito女性及男性青少年颈椎骨龄的回归方程的适用性;若Mito方程不适用,则运用多元逐步回归分析推导出乌鲁木齐市维吾尔族青少年颈椎骨龄的回归方程。第二部分:选取2020年11月~2022年12月就诊于乌鲁木齐市口腔医院正畸科的7~16岁的维吾尔族青少年患者192例(男91例,女101例)。将第三、第四颈椎测量值代入第一部分所得的青少年颈椎骨龄回归方程,分析生物年龄与颈椎骨龄之间的相关关系。结果第一部分:通过Mito提出的女性及男性青少年颈椎骨龄的回归方程得出预估年龄,与生物年龄进行配对分析结果显示女性及男性青少年颈椎骨龄的预估年龄与生物年龄有差异,差异具有统计学意义。将样本实际年龄作为因变量,第三、第四锥体各测量比值做为自变量,使用多元逐步回归分析方法推导出乌鲁木齐市维吾尔族青少年颈椎骨骨龄计算方程。男性:CVBA=2.551-2.151×AH_(3)/AP_(3)+8.884×H4/AP4+3.198×H_(3)/PH_(3),(R=0.804);女性:CVBA=3.607+2.743×H_(3)/AP_(3)+9.967×H4/AP4-3.135×H_(4)/PH_(4),(R=0.792)。第二部分:通过Spearman相关性分析,男性颈椎骨龄与生物年龄之间呈现高度相关(r=0.821,P<0.05);女性颈椎骨龄与生物年龄之间呈�Objective To explore the common parameters of cervical spine bone age of Uighur adolescents in Urumqi,derive the regression equation of cervical spine bone age of Uighur adolescents in Urumqi,and evaluate the significance of its application in prediction of biological age.Methods Part I:A total of 300 Uygur adolescent patients(150 males and 150 females)aged 7~16 years who were admitted to the orthodontic Department of Urumqi Stomatology Hospital from January 2017 to October 2020 were selected.Fixed point measurements were performed on the third and fourth cervical vertebrae(AH3,PH3,AP3,H3,AH4,PH4,AP4,H4).The corresponding ratios representing the morphological changes of cervical cone were obtained(AH3/AP3,AH3/H3,H3/AP3,H3/PH3,PH3/AP3,AH4/AP4,AH4/H4,H4/AP4,PH4/AP4).The ratio data were substituted into the regression equations proposed by Mito for cervical spine bone age in female and male adolescents,and the estimated age and biological age were paired to evaluate the applicability of the regression equations for cervical spine bone age in female and male adolescents.If Mito equation is not applicable,multiple stepwise regression analysis is used to deduce the regression equation of cervical bone age of Uygur teenagers in Urumqi city.Part II:A total of 192 Uygur adolescent patients(91 males and 101 females)aged 7~16 years old who were admitted to the orthodontic Department of Urumqi Stomatology Hospital from November 2020 to December 2022 were selected.The measured values of the third and fourth cervical vertebrae were substituted into the regression equation of adolescent cervical bone age obtained in part I to analyze the correlation between biological age and cervical bone age.Results Part I:The estimated age was obtained through the regression equation of cervical spine bone age of female and male adolescents proposed by Mito.The matching analysis results with biological age showed that the estimated age of cervical spine bone age of female and male adolescents was different from biological age,and the differe

关 键 词：年龄测定 颈椎骨龄 生物年龄 生长发育 维吾尔族 

分 类 号：D919.6[医药卫生—法医学]