3D free-assembly modular microfluidics inspired by movable type printing  

作　　者：Shaoqi Huang Jiandong Wu Lulu Zheng Yan Long Junyi Chen Jianlang Li Bo Dai Francis Lin Songlin Zhuang Dawei Zhang 

机构地区：[1]Engineering Research Center of Optical Instrument and System,the Ministry of Education,Shanghai Key Laboratory of Modern Optical System,University of Shanghai for Science and Technology,Shanghai 200093,China [2]Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [3]Department of Physics and Astronomy,University of Manitoba,Winnipeg,MB R3T 2N2,Canada

出　　处：《Microsystems & Nanoengineering》2023年第5期191-201,共11页微系统与纳米工程（英文）

基　　金：supported by grants from the National Special Fund for the Development of Major Research Equipment and Instrument(Grant No.2020YFF01014503);National Natural Science Foundation of China(Grant No.61775140);Shanghai Industrial Collaborative Innovation Project(Grant No.2021-cyxt1-kj06);Shanghai Rising-Star Program(Grant No.20QA1407000).

摘　　要：Reconfigurable modular microfluidics presents an opportunity for flexibly constructing prototypes of advanced microfluidic systems.Nevertheless,the strategy of directly integrating modules cannot easily fulfill the requirements of common applications,e.g.,the incorporation of materials with biochemical compatibility and optical transparency and the execution of small batch production of disposable chips for laboratory trials and initial tests.Here,we propose a manufacturing scheme inspired by the movable type printing technique to realize 3D free-assembly modular microfluidics.Double-layer 3D microfluidic structures can be produced by replicating the assembled molds.A library of modularized molds is presented for flow control,droplet generation and manipulation and cell trapping and coculture.In addition,a variety of modularized attachments,including valves,light sources and microscopic cameras,have been developed with the capability to be mounted onto chips on demand.Microfluidic systems,including those for concentration gradient generation,droplet-based microfluidics,cell trapping and drug screening,are demonstrated.This scheme enables rapid prototyping of microfluidic systems and construction of on-chip research platforms,with the intent of achieving high efficiency of proof-of-concept tests and small batch manufacturing.

关 键 词：BATCH PROOF mounted 

分 类 号：O15[理学—数学]