RUNX家族在调控T细胞发育中的研究进展  

Research progress of RUNX family on regulation of T cell development

作　　者：李安 李源 陈陆俊[1] 蒋敬庭[1] 郑晓[1] LI An;LI Yuan;CHEN Lu-jun;JIANG Jing-ting;ZHENG Xiao(Department of Tumor Biological Treatment,the Third Affiliated Hospital of Soochow University,Jiangsu Engineering Research Center for Tumor Immunotherapy,Institute of Cell Therapy,Soochow University,Changzhou 213003,China)

机构地区：[1]苏州大学附属第三医院肿瘤生物诊疗中心,江苏省肿瘤免疫治疗工程技术研究中心,苏州大学细胞治疗研究院,常州213003

出　　处：《现代免疫学》2023年第6期529-532,537,共5页Current Immunology

基　　金：国家自然科学基金面上项目(82172689);国家自然科学基金青年科学基金项目(81902386);江苏省自然科学基金项目(BK20211065);中国博士后科学基金面上项目(2021M700543,2021M700547);江苏省“六个一工程”拔尖人才项目(LGY2020034);常州市国际科技合作项目(CZ20210035);常州市社会发展科技支撑项目(CE20215030)。

摘　　要：Runt相关转录因子(Runt-related transcription factor,RUNX)是胚胎发育过程中的主要调节因子,同时也是所有造血谱系所必需的调节因子,其基因突变与多种疾病发生有关。RUNX转录因子家族由Runx1、Runx2和Runx3组成。RUNX蛋白通过调控CD4^(+)T细胞和CD8^(+)T细胞的发育和分化,参与适应性免疫系统的形成。该文主要就RUNX家族成员在T细胞发育过程中的调控机制进行综述。Runt related transcription factor(RUNX)is the main regulator during embryonic development and is essential for the development of all hematopoietic lineages.Mutation of RUNX is associated with a variety of diseases.The RUNX transcription factor family consists of Runx1,Runx2,and Runx3.The RUNX protein participates in the formation of the adaptive immune system by regulating the development and differentiation of CD4^(+)and CD8^(+)T cells.This article mainly reviews the regulatory mechanisms of RUNX family members in T cell development.

关 键 词：Runt相关转录因子1 Runt相关转录因子2 RUNT相关转录因子3 T细胞 

分 类 号：R392.1[医药卫生—免疫学]