血清FAR与NT-proBNP联合对NSTE-ACS患者首次介入术后预后的预测意义  

Predictive significance of serum FAR combined with NT-proBNP on the prognosis of patients with NSTE-ACS after primary intervention

作　　者：王丽[1] 马兴雅 Wang Li;Ma Xing-ya(The Sixth People's Hospital of Zhengzhou,Zhengzhou 450015,China)

机构地区：[1]郑州市第六人民医院,河南郑州450015

出　　处：《四川生理科学杂志》2023年第12期2285-2288,2308,共5页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨血清纤维蛋白原/白蛋白比值(Fibrinogen albumin ratio,FAR)与N末端脑利肽前体(Nterminal pro-brain natriuretic peptide,NT-proBNP)对非ST段抬高性急性冠状动脉综合征(Non-ST-segment elevation acute coronary syndrome,NSTE-ACS)患者首次介入术后的预后的预测意义。方法:纳入2019年6月至2021年6月经本院收治120例首次经皮冠状动脉介入治疗(Percutaneous coronary intervention,PCI)NSTE-ACS患者,按不良心血管事件(Major adverse cardiovascular events,MACE)是否发生分为预后良好组及预后不良组,行单因素及Logistic回归模型多因素分析预后影响因素,运用受试者工作特征(Receiver operating characteristics,ROC)曲线评估FAR及NT-proBNP单一及联合预测价值。结果:经单因素及Logistic回归模型多因素分析显示:影响NSTE-ACS患者PCI预后独立性风险因素为FAR、NT-proBNP;经ROC分析结果显示,FAR联合NT-proBNP预测NSTE-ACS患者PCI近期预后价值最高,AUC值为0.968,灵敏度、特异度分别为91.67%、90.48%。结论:NSTE-ACS患者PCI预后不良与FAR与NT-proBNP密切相关,将FAR与NT-proBNP联合预测预后不良具有较高诊断效能。Objective:To investigate the effect of serum fibrinogen albumin ratio(FAR)and N-terminal pro-brain natriuretic peptide(NT-proBNP)on patients with non-ST-segment elevation acute coronary syndrome(NSTE-ACS)after primary intervention predictive significance of the prognosis.Methods:A total of 120 patients with NSTE-ACS who underwent percutaneous coronary intervention(PCI)for the first time from June 2019 to June 2021 in our hospital,according to the occurrence of major adverse cardiovascular events(MACE)were included and divided into a good prognosis group and poor prognosis group.Univariate and logistic regression models were used for multivariate analysis.Prognostic factors,and the single and combined predictive value of FAR and NT-proBNP were assessed by Receiver operating characteristics(ROC)curve.Results:The multivariate analysis of univariate and Logistic regression model showed that the independent risk factors affecting the prognosis of PCI in NSTE-ACS patients were FAR and NT-proBNP;the ROC analysis showed that FAR combined with NT-proBNP predicted the short-term prognosis of PCI in NSTE-ACS patients.It has the highest prognostic value,with AUC value of 0.968,sensitivity and specificity of 91.67%and 90.48%,respectively.Conclusion:The poor prognosis of PCI in NSTE-ACS patients is closely related to FAR and NT-proBNP,and the combination of FAR and NT-proBNP has high diagnostic performance in predicting poor prognosis.

关 键 词：非ST段抬高性急性冠状动脉综合征 血清纤维蛋白原/白蛋白比值 N末端脑利肽前体 经皮冠状动脉介入治疗 不良心血管事件 

分 类 号：R54[医药卫生—心血管疾病]