光泵磁强计双轴探测听觉诱发脑磁信号的初步探索  

Biaxial Magnetoencephalography Acquisition of Auditory Evoked Responses Using Optically Pumped Magnetometer:a Preliminary Study

作　　者：王天宇 郑昱[4,5] 杨思嘉 张力伟 王帆 WANG Tian-Yu;ZHENG Yu;YANG Si-Jia;ZHANG Li-Wei;WANG Fan(School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China;Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Beijing Neurosurgical Institute,Beijing 100070,China;Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]北京航空航天大学生物与医学工程学院,北京100191 [2]首都医科大学附属北京天坛医院神经外科,北京100070 [3]北京市神经外科研究所,北京100070 [4]中国科学院生物物理研究所,北京100101 [5]中国科学院大学,北京100049

出　　处：《生物化学与生物物理进展》2023年第12期3023-3031,共9页Progress In Biochemistry and Biophysics

基　　金：科技部重点研发计划(2019YFA0707103,2020AAA0105601);国家自然科学基金(31730039,U21A20388);中国科学院项目(XDB32010300,ZDBS-LY-SM028);科技创新2030重大项目(2022ZD0211901);北京市自然科学基金(Z210009)资助。

摘　　要：目的光泵磁强计(optically pumped magnetometer,OPM)脑磁图(magnetoencephalography,MEG)作为新一代脑功能成像技术,在多轴探测设计下具备了对传统MEG信号“盲区”的检测能力,为脑内功能活动研究提供更全面的技术工具。本文旨在探讨双轴OPM-MEG在测量真实生理反应时的信号分布差异特征。方法采用9通道OPM-MEG对10名健康受试者的听觉相关频率跟随反应进行检测。通过每个被试1000个试次的数据采集,获取所有通道头皮切向(Y轴)和径向(Z轴)的磁响应信号。结果研究显示,双轴OPM-MEG记录到的信号在强度和分布上与传统MEG存在明显区别。双轴信号明显强于传统MEG,且传统MEG难以记录的切向信号显著强于径向信号。结论本研究证实了双轴OPM-MEG在测量真实生理信号方面的能力,并且双轴测量能够获取更丰富的信息,特别是可能存在于传统MEG测量盲区中的脑功能活动信号。这为基于传统MEG记录的神经电活动模型带来了重大更新。双轴OPM-MEG的多轴记录特性在脑科学研究和脑疾病诊断领域都具有巨大的应用潜力。这项研究初步展示了双轴OPM-MEG在听觉诱发信号研究中的价值,为后续深入研究奠定了基础。Objective Optically pumped magnetometer(OPM)-magnetoencephalography(MEG)is a rapidly developing new-generation brain function imaging technology compared to the traditional MEG.Due to the proximity of the detectors and the scalp,OPM-MEG offers higher signal intensity and,with its multiaxis detection capability,can detect signals in the“blind area”of traditional MEG.It provides a powerful tool to the research of brain function and clinical diagnosis.This paper aims to investigate the signal distribution differences of biaxial OPM-MEG when measuring true physiological responses and to compare its performance with traditional MEG.Methods In this study,ten healthy subjects were examined using a 9-channel biaxial OPM-MEG during an auditory task involving frequency following responses(FFR).FFR-related magnetic responses were acquired along both tangential(Y-axis)and radial(Z-axis)directions.We analyzed the OPM-MEG data features in different axial directions and different regions,including signal intensity and regional mean energy.Additionally,we compared the results with the data detected by traditional MEG.Results After processing 800 trials,the average signal energy in the Y-axis and Z-axis was found to be 0.9710 and 0.7673 respectively,with no statistical significance(P=0.438).However,a regional analysis revealed distinct signal distribution patterns in the left temporal area compared to the other two regions,which was statistically significant(P=0.049).Topographical mapping showed a clear left-sided lateralization,similar to SQUID-MEG results.PSD analysis and wavelet time-frequency analysis further supported these findings.In-depth analysis of peak-to-peak values from all sensors during the stimulus period(0-0.2 s)revealed that within-participant measurements showed consistency,whereas between-participant variability was considerable.This highlights the importance of considering individual differences in future studies,as they can significantly impact measurement outcomes.The analysis revealed that the biaxial

关 键 词：脑磁图 光泵磁强计 频率跟随反应 双轴传感器 

分 类 号：R338[医药卫生—人体生理学] TH77[医药卫生—基础医学]