不同脂肪乳在肠外营养液中稳定性的研究  

Study on the stability of different fat emulsions in parenteral nutrition

作　　者：刘思彤 周达 王慧 曹舒雨 陈华 司婷 陈静 靳晓桐 叶向红 王新颖 Liu Sitong;Zhou Da;Wang Hui;Cao Shuyu;Chen Hua;Si Ting;Chen Jing;Jin Xiaotong;Ye Xianghong;Wang Xinying(Department of General Surgery,PLA General Hospital of Eastern Theater,Nanjing 210002,China)

机构地区：[1]解放军东部战区总医院普通外科,南京210002

出　　处：《中华临床营养杂志》2023年第5期290-293,306,共5页Chinese Journal of Clinical Nutrition

摘　　要：目的观察肠外营养液配制后在不同存放温度条件下脂肪乳的稳定性。方法采用规范化肠外营养液配制,共配制24袋肠外营养液,随机分为两组,A组12袋配方中脂肪乳为20%中/长链脂肪乳注射液(C6-24),B组12袋配方中脂肪乳为20%中/长链脂肪乳注射液(C8-24),检测时间点为配制完成后24、48、72 h,观察两组在2~8℃,23~25℃和35~37℃中外观、营养液pH值和脂质过氧化。结果两组在4℃、25℃和36℃条件下分别放置24、48、72 h后,外观均无明显变化,pH值差异无统计学意义(P>0.05),脂质过氧化差异无统计学意义(P>0.05)。结论两种脂肪乳在不同存放条件下pH值、脂肪颗粒大小、脂质过氧化产物方面都较为稳定,能够为进行静脉营养支持患者提供营养物质需求。Objective To investigate the stability of fat emulsions after the preparation of parenteral nutrient solution under different storage conditions.Methods Standardized parenteral nutrient solution was used to prepare a total of 24 bags of nutrient solution with the same formula,except for that Group A(12 bags)contains 20%of medium and long chain fat emulsion(C6-24)while Group B contains 20%of C8-24.The preparations were stored under 2-8℃,23-25℃,and 35-37℃and were examined at 24h,48h and 72h after preparation.The appearance,average size of fat particles,pH value of nutrient solution,and lipid peroxidation were investigated.Results After storage at 4℃,25℃and 36℃for 24h,48h and 72h respectively,both groups of preparations showed no obvious change in appearance.There was no significant difference in pH(P>0.05)nor lipid peroxidation(P>0.05).Conclusion Both kinds of fat emulsion are stable in terms of pH value,fat particle size and lipid peroxidation,and can be used for patients receiving intravenous nutrition support.

关 键 词：肠外营养液 中链脂肪乳 长链脂肪乳 

分 类 号：R459.3[医药卫生—治疗学]