Plackett-Burman设计结合Box-Behnken响应面法筛选草乌甲素纳米乳凝胶贴膏的处方  

Screening the prescription of bulleyaconitine A nanoemulsion gel paste by Plackett- Burman design and Box-Behnken response surface methodology

作　　者：何雨晓 李丽云 孙文强 丁江生 周云龙 HE Yuxiao;LI Liyun;SUN Wenqiang;DING Jiangsheng;ZHOU Yunlong(Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Yunnan Provincial Institute of Pharmacy,Kun-ming 650111,China;Key Laboratory of Traditional Chinese Medicine and Ethnic Medicine New Drug Creation Enterprises in Yunnan Province,Kunming 650111,China)

机构地区：[1]云南中医药大学,昆明650500 [2]云南省药物研究所,昆明650111 [3]云南省中药和民族药新药创制企业重点实验室,昆明650111

出　　处：《西北药学杂志》2024年第1期92-98,共7页Northwest Pharmaceutical Journal

基　　金：云南省科技厅科技计划项目(编号:2019DC008)。

摘　　要：目的优化草乌甲素纳米乳凝胶贴膏基质的处方。方法在Plackett-Burman设计、最陡爬坡实验的基础上,以甘油、酒石酸、纯化水用量作为变量,以初黏力、持黏力、感官评价的综合评分为评价指标,用Box-Behnken响应面法优化草乌甲素纳米乳凝胶贴膏基质的处方。结果最优处方为甘油用量40.877 g,酒石酸用量0.294 g,纯化水用量42.491 g,综合评分为94.937分。结论建立的方法稳定、可靠、预测性能优良,此方法可用于优化草乌甲素纳米乳凝胶贴膏基质的处方。Objective To optimize the prescription of bulleyaconitine A nanoemulsion gel paste.Methods On the basis of Plackett-Burman design and the steepest climbing experiment,the dosage of glycerol,tartaric acid and purified water was used as the influencing factors,and the comprehensive score of initial viscosity,viscosity retention and sensory evaluation was used as the evaluation index.Box-Behnken response surface method was used to optimize the matrix prescription.Results The optimal prescription was 40.877 g of glycerol,0.294 g of tartaric acid and 42.491 g of purified water.The comprehensive score was 94.937.Conclusion The method is simple,feasible and predictive,and can be used to optimize the matrix formulation of bulleyaconitine A nanoemulsion gel paste.

关 键 词：草乌甲素 纳米乳 凝胶贴膏 PLACKETT-BURMAN设计 

分 类 号：R94[医药卫生—药剂学]