加巴喷丁联合依帕司他治疗痛性糖尿病周围神经病变的效果  

Effect of gabapentin and epalrestat in the treatment of painful diabetic peripheral neuropathy

作　　者：孙仰婷 刘晓英 龙尚丽 李智明[2] SUN Yangting;LIU Xiaoying;LONG Shangli;LI Zhiming(The 3rd Internal Department,Dongfang People’s Hospital,Dongfang 572600,China;Department of Endocrine,Haikou Affiliated Hospital of Central South University Xiangya School of Medicine,Haikou 570208,China)

机构地区：[1]东方市人民医院内三科,东方572600 [2]中南大学湘雅医学院附属海口医院内分泌科,海口570208

出　　处：《西北药学杂志》2024年第1期143-146,共4页Northwest Pharmaceutical Journal

基　　金：海南省卫生计生行业科研项目(编号:16A200094)。

摘　　要：目的探究加巴喷丁联合依帕司他、甲钴胺治疗痛性糖尿病周围神经病变(painful diabetic peripheral neuropathy,PDPN)的疗效。方法选取96例PDPN患者,用随机分组法分为观察组(n=42)与对照组(n=54),对照组用加巴喷丁联合甲钴胺治疗,观察组在对照组治疗的基础上加用依帕司他。观察2组患者用药后的神经传导速度、视觉模拟评分(visual analogue scale,VAS)、不良反应发生率、生活质量和临床疗效。结果治疗3、6周后,观察组的VAS显著低于对照组(P<0.05)。治疗6周后,2组运动神经传导速度和感觉神经传导速度均有显著提升;且观察组的运动神经传导速度和感觉神经传导速度均显著快于对照组(P<0.05)。治疗后,观察组(1.85%)与对照组(4.76%)不良反应发生率比较差异无统计学意义(P>0.05)。治疗6周后,观察组(95.23%)与对照组(90.73%)的总有效率比较差异无统计学意义(P>0.05)。治疗6周后,2组的生理、心理、社会、疾病和满意度各维度得分均显著高于治疗前,且观察组的得分显著高于对照组(P<0.05)。结论加巴喷丁联合依帕司他、甲钴胺治疗可缓解PDPN患者的疼痛,改善神经功能,提高患者日常生活质量,值得临床推广。Objective To explore the efficacy of gabapentin combined with epalrestat and mecobalamin in the treatment of painful diabetic peripheral neuropathy(PDPN).Methods 96 patients with PDPN were randomly divided into observation group(n=42)and control group(n=54).The control group was treated with gabapentin combined with mecobalamin,and the observation group was treated with epalrestat on the basis of the control group.The nerve conduction velocity,visual analogue scale(VAS),adverse reaction rate,quality of life and clinical efficacy of the 2 groups were observed.Results After 3 and 6 weeks of treatment,the VAS of the observation group was significantly lower than that of the control group(P<0.05).After 6 weeks of treatment,motor nerve conduction velocity and sensory nerve velocity were significantly increased in both groups;The conduction velocities of motor and sensory nerves in the observation group were significantly faster than those in the control group(P<0.05).After treatment,there was no significant difference in the incidence of adverse reactions between the observation group(1.85%)and the control group(4.76%).After 6 weeks of treatment,there was no significant difference in the total effective rate between the observation group(95.23%)and the control group(90.73%)(P>0.05).After 6 weeks of treatment,the scores of physiological,psychological,social,disease and satisfaction dimensions were significantly higher than those before treatment,and the scores of the observation group were significantly higher than those of the control group(P<0.05).Conclusion Gabapentin combined with epalrestat and mecobalamin can relieve pain,improve neurological function,and improve the quality of daily life of patients with PDPN,which is worthy of clinical promotion.

关 键 词：加巴喷丁 依帕司他 甲钴胺 痛性糖尿病周围神经病变 

分 类 号：R971[医药卫生—药品]