血必净注射液联合乙酰半胱氨酸对急性百草枯中毒肝肾损伤的作用  

Effect of Xuebijing Injections combined with acetylcysteine on liver and kidney damage in acute paraquat poisoning

作　　者：龚升玄 魏书堂 GONG Shengxuan;WEI Shutang(Department of Emergency,Nanyang First People’s Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院急诊科,南阳473000

出　　处：《西北药学杂志》2024年第1期147-150,共4页Northwest Pharmaceutical Journal

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20190532)。

摘　　要：目的探讨血必净注射液联合乙酰半胱氨酸(acetylcysteine,AC)对急性百草枯中毒(acute paraquat poisoning,APP)肝肾损伤的作用。方法回顾性分析救治的80例APP患者的临床资料,按治疗方式不同分为AC组(n=39,常规治疗联合AC)、联合组(n=41,在AC组治疗的基础上加用血必净注射液)。比较2组治疗前、治疗2周后呼吸指标[动脉血氧分压(PaO_(2))、氧合指数]、炎症因子水平[白细胞介素-6(interleukin-6,IL-6)、转化生长因子β_(1)(transforming growth factor-β_(1),TGF-β_(1))]和肝肾功能指标[丙氨酸氨基转移酶(glutamic pyruvic transaminase,GPT)、天冬氨酸氨基转移酶(glutamic oxaloacetic transaminase,GOT)、血肌酐(serum creatinine,Scr)和肾小球滤过率(estimated glomerular filtration rate,eGFR)],并观察预后。结果治疗后,2组PaO_(2)、氧合指数和eGFR均较治疗前明显升高(P<0.05),且联合组均明显高于AC组(P<0.05);治疗后,2组血清IL-6、TGF-β_(1)水平和GPT、GOT、Scr均较治疗前明显降低(P<0.05),且联合组均明显低于AC组(P<0.05);联合组1个月内脏器功能衰竭发生率(32.56%vs.56.41%)、病死率(60.98%vs.82.05%)均明显低于AC组(P<0.05)。结论血必净注射液联合AC治疗APP,可明显减轻肝肾损伤,有效抑制炎症反应,显著提高患者的存活率。Objective To investigate the effect of Xuebijing Injections combined with acetylcysteine(AC)on liver and kidney damage in acute paraquat poisoning(APP).Methods The clinical data of 80 patients with APP were retrospectively analyzed and divided into AC group(n=39,conventional treatment and AC)and combined group(n=41,Xuebijing Injection was added on the basis of AC group treatment)according to different treatment methods.The respiratory indexes[arterial blood partial pressure of oxygen(PaO_(2))and oxygenation index],inflammatory factor levels[interleukin-6(IL-6)and transforming growth factor-β_(1)(TGF-β_(1))],liver and kidney function indicators[glutamic pyruvic transaminase(GPT),glutamic oxaloacetic transaminase(GOT),serum creatinine(Scr),and estimated glomerular filtration rate(eGFR)]were compared between the 2 groups before treatment and after 2 weeks of treatment,and the prognosis were observed.Results After treatment,the PaO_(2),oxygenation index,and eGFR in the 2 groups were significantly higher than those before treatment(P<0.05),and the combined group were obviously higher than the AC group(P<0.05);after treatment,the levels of serum IL-6 and TGF-β_(1) and the measured values of GPT,GOT and Scr in the 2 groups were significantly lower than those before treatment(P<0.05),and the combination group were significantly lower than the AC group(P<0.05);the incidence of organ failure(32.56%vs.56.41%)and the mortality rate(60.98%vs.82.05%)within 1 month in the combined group were significantly lower than those in the AC group(P<0.05).Conclusion Xuebijing Injections combined with AC therapy for APP patients can significantly reduce liver and kidney damage,effectively inhibit inflammatory response,and improve the survival rate of patients.

关 键 词：血必净注射液 乙酰半胱氨酸 急性百草枯中毒 肝肾损伤 

分 类 号：R97[医药卫生—药品]