八正片联合坦洛新片治疗输尿管壁内段结石的效果  

Effect of Bazheng Tablets combined with Tamsulosin Tablets in the treatment of ureterovesical junction stones

作　　者：宋群 杨海蛟 蒋颖 李卓[1] SONG Qun;YANG Haijiao;JIANG Ying;LI Zhuo(Department of Urology,Hu’nan Provincial People’s Hospital,Changsha 410000,China;Department of Urology,Shimen County Hospital of Traditional Chinese Medicine,Changde 415000,China)

机构地区：[1]湖南省人民医院泌尿外科,长沙410000 [2]石门县中医医院泌尿外科,常德415000

出　　处：《西北药学杂志》2024年第1期171-175,共5页Northwest Pharmaceutical Journal

基　　金：湖南创新型省份建设专项(编号:2021ZK4061)。

摘　　要：目的探讨八正片联合坦洛新片治疗输尿管壁内段结石的临床疗效。方法选取确诊输尿管壁内段结石的患者93例,其中90例患者符合纳入标准,用随机分组法分为对照组(n=45)和观察组(n=45)。2组患者采用体外冲击波碎石后,对照组患者口服坦洛新片,观察组口服八正片联合坦洛新片,均持续治疗15 d。治疗后,评估2组患者的临床疗效。比较2组中医证候积分及结石排净率;统计2组肾绞痛发作率、抗生素使用率、止痛药使用率、结石排净时间、抗生素使用时间及视觉模拟疼痛(visual analogue scale,VAS)评分;比较2组患者治疗前后的肾功能指标(肌酐、尿素氮)及尿生化指标(尿酸、尿草酸和尿钙)水平。记录2组治疗期间并发症发生情况。结果观察组的治疗有效率(95.56%)高于对照组(82.22%),P<0.05;观察组各项中医证候积分明显低于对照组,且各时间点结石排净率均高于对照组(P<0.05);观察组肾绞痛发作率、抗生素使用率、止痛药使用率、结石排净时间、抗生素使用时间及用药3、5 d的VAS评分明显低于对照组(P<0.05);观察组输尿管壁内段结石患者肌酐、尿素氮及尿酸、尿草酸和尿钙水平明显低于对照组(P<0.05);观察组并发症的发生率为15.56%,高于对照组的11.11%(P>0.05)。结论八正片联合坦洛新片治疗输尿管壁内段结石疗效显著,可缓解症状,提高结石排净率。Objective To explore the efficacy of Bazheng Tablets combined with Tamsulosin Tablets on ureterovesical junction stones.Methods A total of 93 patients confirmed with ureterovesical junction stones were enrolled,including 90 cases meeting the inclusion criteria.According to random grouping method,they were divided into control group(45 cases)and observation group(45 cases).After extracorporeal shock wave lithotripsy,the control group was given Tamsulosin Tablets orally,while the observation group was additionally given Bazheng Tablets orally.All were continuously treated for 15 days.After treatment,the clinical curative effect in both groups was evaluated.The scores of traditional Chinese medicine(TCM)syndromes and stone clearance rate between the 2 groups were compared.The incidence of renal colic,usage rates of antibiotics and analgesics,spending time of stone clearance,usage time of antibiotics and score of visual analogue scale(VAS)in both groups were statistically analyzed.The levels of renal function indexes(creatinine and blood urea nitrogen)and urine biochemical indexes(uric acid,urinary oxalic acid,and urinary calcium)were compared between the 2 groups before and after treatment.The occurrence of complications during treatment in both groups was recorded.Results The response rate of treatment in observation group was higher than that in control group(95.56%vs.82.22%)(P<0.05).The scores of TCM syndromes in observation group were significantly lower than those in control group,and stone clearance rate was higher than that in control group(P<0.05).The incidence of renal colic,usage rates of antibiotics and analgesics,spending time of stone clearance,usage time of antibiotics and score of VAS scores after 3 days and 5 days of medication in observation group were significantly lower than those in control group(P<0.05).After treatment,the levels of creatinine,blood urea nitrogen,uric acid,urinary oxalic acid and urinary calcium in observation group were significantly lower than those in control group(P<0.05),an

关 键 词：八正片 坦洛新片 输尿管壁内段结石 体外冲击波碎石 

分 类 号：R983[医药卫生—药品]