琥珀酰亚胺衍生物抗癫痫活性的研究进展  

Research progress of anti-epileptic activity succinimide derivatives

作　　者：王咏琪 赵泽丰 年梦 陈靖轩[1,2] 乔海法 杨晓航 WANG Yongqi;ZHAO Zefeng;NIAN Meng;CHEN Jingxuan;QIAO Haifa;YANG Xiaohang(Shaanxi Key Laboratory of Acupuncture&Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,China;College of Acupuncture&Massage,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西省针药结合重点实验室,咸阳712046 [2]陕西中医药大学针灸推拿学院,咸阳712046

出　　处：《西北药学杂志》2024年第1期221-227,共7页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:8210142829);陕西省自然科学基础研究项目(编号:2022JQ-823);陕西省教育厅科研计划项目(编号:21JS020);陕西中医药大学经脉-脏腑相关研究创新团队项目(编号:YL-09);陕西省科技厅中医诊疗装备研发相关研究创新团队项目(编号:303-202210705)。

摘　　要：目的对琥珀酰亚胺衍生物的抗癫痫活性进行总结。方法通过收集已发表文献中报道的琥珀酰亚胺衍生物的相关信息,对琥珀酰亚胺衍生物的抗癫痫活性及构效关系进行综述。结果按照时间顺序,对文献报道的25种琥珀酰亚胺类衍生物的抗癫痫活性进行了系统性的总结。结论通过对琥珀酰亚胺衍生物活性及构效关系的总结,为进一步开发以琥珀酰亚胺为母核的新型抗癫痫药物提供依据。Objective To summarize the antiepileptic activity of succinimide derivatives.Methods By gathering relevant information of succinimide derivatives reported in published literatures,the antiepileptic activity and structure-activity relationship(SAR)of succinimide derivatives were summarized.Results The antiepileptic activities of 25 succinimide derivatives were systematically summarized in chronological order.Conclusion Summarizing the activity and SAR of succinimide derivatives lays a foundation for further development of new antiepileptic drugs with succinimide as the parent nucleus.

关 键 词：琥珀酰亚胺衍生物 抗癫痫 构效关系 

分 类 号：R971[医药卫生—药品]