甲泼尼龙穴位注射联合基础治疗对哮喘急性重度发作的临床研究  

Clinical Study on Point Injection of Methylprednisolone Combined with Basic Treat⁃ment for Acute Severe Asthma Attack

作　　者：邱丽燕 杨东孝 徐晓霞[1] QIU Liyan;YANG Dongxiao;XU Xiaoxia(Department of Pulmonary Disease,Sisheng Bianji Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,Quzhou Zhejiang 324001)

机构地区：[1]浙江中医药大学附属四省边际中医院肺病科,浙江衢州324001

出　　处：《新中医》2023年第23期200-204,共5页New Chinese Medicine

基　　金：浙江中医药大学校级项目(2021FSYYZZ19)。

摘　　要：目的:观察甲泼尼龙穴位注射联合基础治疗对哮喘急性重度发作患者的临床疗效及对患者肺功能、生活质量的影响。方法:选取80例哮喘急性重度发作患者为研究对象,按随机数字表法分为对照组及试验组各40例。对照组在维持常规中西药方案基础上给予注射用甲泼尼龙琥珀酸钠静脉注射治疗,试验组在常规中西药方案基础上给予注射用甲泼尼龙碱珀酸钠穴位注射治疗。比较2组临床疗效及不良反应发生情况,比较2组治疗前后肺功能指标及哮喘控制测试评分(ACT)、圣乔治呼吸问卷(SGRQ)评分。结果:治疗后试验组总有效率95.00%,高于对照组80.00%(P<0.05)。治疗后,2组呼气峰流速(PEF)、第1秒用力呼气容积(FEV_(1))和第1秒用力呼气容积占用力肺活量百分比(FEV_(1)/FVC)均升高(P<0.05),且试验组高于对照组(P<0.05)。治疗后,2组SGRQ评分下降(P<0.05),ACT评分升高(P<0.05),且试验组SGRQ评分低于对照组(P<0.05),ACT评分高于对照组(P<0.05)。试验组哮喘持续时间和住院时间均短于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:甲泼尼龙穴位注射联合基础治疗能够提高哮喘急性重度发作患者的临床疗效,快速缓解急性发作症状,恢复肺功能,提高生活质量,且不增加不良反应。Objective:To observe the clinical effect of point injection of methylprednisolone combined with basic treatment on patients with acute severe asthma attack and the effects on their lung function and quality of life.Methods:A total of 80 cases of patients with acute severe asthma attack were selected as the study objects and divided into the control group and the trail group according to the random number table method,with 40 cases in each group.On the basis of maintaining the conventional Chinese and western medicine regimen,The control group additionally received intravenous injection of Methylprednisolone Sodium Succinate for Injection,and the trial group was additionally treated with point injection of Methylprednisolone Sodium Succinate for Injection.Clinical effects and the incidence of adverse reactions were compared between the two groups.The lung function indicators and the scores of the Asthma Control Test(ACT)and St.George's Respiratory Questionnaire(SGRQ)were compared between the two groups before and after treatment.Results:The total effective rate was 95.00%in the trial group,higher than that of 80.00%in the control group(P<0.05).After treatment,peak expiratory flow(PEF),the forced expiratory volume in one second(FEV_(1)),and the ratio of forced expiratory volume in one second to forced vital capacity(FEV_(1)/FVC)in the two groups were increased(P<0.05),and the above three indexes in the trial group were higher than those in the control group(P<0.05).After treatment,the SGRQ scores in the two groups were decreased(P<0.05),and the ACT scores were increased(P<0.05);the SGRQ score in the trial group was lower than that in the control group(P<0.05),and the ACT score in the trial group was higher than that in the control group(P<0.05).The duration of asthma and hospitalization time in the trial group were shorter than those in the control group(P<0.05).There was no significant difference being found in the comparison of the incidence of adverse reactions(P>0.05).Conclusion:For patients with acute severe a

关 键 词：哮喘 急性重度发作 甲泼尼龙 穴位注射 肺功能 生活质量 

分 类 号：R246.1[医药卫生—针灸推拿学]