射频靶点热凝扩容法联合壮腰强督汤治疗肾气亏虚型腰椎管狭窄症的临床研究  

Clinical Study of Radiofrequency Targeted Thermocoagulation and Volume Expansion Method Combined with Strengthening the Waist and Strengthening the Supervisors Tang in the Treatment of Lumbar Spinal Stenosis with Deficiency of Kidney Qi

作　　者：霍亮 李煜 崔文慧 李高明 Huo Liang;Li Yu;Cui Wenhui(Orthopedic Ward 5,Kaifeng Second Chinese Medicine Hospital,Kaifeng,Henan,475000,China)

机构地区：[1]开封市第二中医院骨五病区,河南开封475000

出　　处：《黑龙江医学》2024年第1期27-30,共4页Heilongjiang Medical Journal

基　　金：开封市科技发展计划项目(2103054)。

摘　　要：目的:探讨射频靶点热凝扩容法联合壮腰强督汤治疗肾气亏虚型腰椎管狭窄症(LSS)的疗效及安全性,并观察对患者机体炎症反应水平的影响。方法:选取2021年1月—2022年1月开封市第二中医院收治的92例肾气亏虚型LSS患者作为研究对象,将其随机分成试验组和对照组,应用常规保守治疗措施的46例患者为对照组,给予射频靶点热凝扩容法与壮腰强督汤联合治疗的46例患者为试验组,对两组患者的临床疗效进行评价,分别于治疗前、治疗4周后、治疗12周后评价疼痛视觉模拟标尺法(VAS)、中医症状积分和日本骨科协会评估治疗分数(JOA评分),采用酶联免疫吸附法检测治疗前及治疗后12周血清白细胞介素(IL-1α)、肿瘤坏死因子(TNF-α)的水平变化,并对治疗安全性进行评价。结果:试验组总有效率较对照组明显升高,差异有统计学意义(χ^(2)=4.841,P<0.05)。治疗后,两组患者VAS评分均降低,差异有统计学意义(t=4.287、7.162,P<0.05);治疗后,两组患者JOA评分均升高,差异有统计学意义(t=11.121、11.630,P<0.05);治疗后,两组患者中医症状积分均降低,差异有统计学意义(t=9.036、18.826,P<0.05);治疗后,两组患者血清IL-1α、TNF-α的水平均降低,差异有统计学意义(t=2.885、0.033,P<0.05)。在治疗安全性方面,两组患者比较,差异无统计学意义(χ^(2)=0.548,P>0.05)。结论:射频靶点热凝扩容法联合壮腰强督汤治疗肾气亏虚型LSS患者取得的疗效显著,有利于改善患者临床症状,降低患者疼痛程度,改善腰椎功能,患者机体炎症反应明显降低,且安全性较高。Objective:To investigate the efficacy and safety of radiofrequency-targeted thermocoagulation and dilatation method combined with Strengthening the Waist and Strengthening the Vertebrae Soup in the treatment of lumbar spinal stenosis(LSS)of the kidney-qi deficiency type,and to observe the effect on the level of inflammatory response of the patients’organism.Methods:92 patients with LSS of the kidney qi deficiency type were collected and randomly divided into a test group and a control group.The 46 patients who applied conventional conservative treatment measures were the control group,and the 46 patients who were given the combined treatment of radiofrequency targeted thermocoagulation and volume expansion method with Strong Waist and Strong Governor Soup were the experimental group.The clinical efficacy of the two groups was evaluated by evaluating the pain visual analog scale method(VAS),Chinese medicine symptom score and Japanese Orthopaedic Association Assessment of Treatment Score(JOA score)before treatment,after 4 weeks of treatment and after 12 weeks of treatment.Changes in the levels of serum interleukin-1α(IL-1α)and tumor necrosis factor-α(TNF-α)were detected by enzyme-linked immunosorbent assay before and 12 weeks after treatment,and the safety of treatment was evaluated.Results:The total effective rate of the test group was significantly higher than that of the control group,and the difference was statistically significant(χ^(2)=4.841,P<0.05).After treatment,VAS scores decreased in both groups,and the difference was statistically significant(t=4.287,7.162,P<0.05).After treatment,JOA scores increased in both groups,and the difference was statistically significant(t=11.121,11.630,P<0.05).After treatment,the TCM symptom scores of patients in both groups were reduced,and the difference was statistically significant(t=9.036,18.826,P<0.05).After treatment,the levels of serum IL-1α and TNF-α were reduced in both groups,and the difference was statistically significant(t=2.885,0.033,P<0.05).There was n

关 键 词：射频靶点热凝扩容法 壮腰强督汤 腰椎管狭窄症 

分 类 号：R68[医药卫生—骨科学]