细胞焦亡在新生儿感染性疾病中的研究进展  

Research Progress of Pyroptosis in Neonatal Infectious Diseases

作　　者：许德博 孟琼 XU Debo;MENG Qiong(Guangdong Medical University,Zhanjiang 524000,China;Department of Pediatrics,Guangdong Second People′s Hospital,Guangzhou 510317,China)

机构地区：[1]广东医科大学,广东湛江524000 [2]广东省第二人民医院儿科,广州510317

出　　处：《医学综述》2024年第1期19-23,共5页Medical Recapitulate

基　　金：广东省基础与应用基础研究基金自然科学基金项目(2022A1515012548)。

摘　　要：新生儿感染性疾病是导致新生儿死亡的主要原因之一,目前临床关于新生儿感染性疾病的诊断缺乏特异性,导致病情进展迅速。细胞焦亡是一种可释放炎症因子的细胞程序性死亡,参与新生儿感染性疾病的发病过程并可加重体内炎症反应,同时也会不同程度地损害组织和器官,抑制细胞焦亡则可减轻局部组织炎症、改善患儿临床症状。因此,深入研究细胞焦亡在新生儿感染性疾病中的作用机制,可以为疾病的临床诊疗提供新思路,改善患儿预后。Neonatal infectious diseases are one of the main causes of neonatal death.At present,the clinical diagnosis of neonatal infectious diseases lacks specificity,which leads to the rapid progress of the diseases.Pyroptosis is a programmed cell death that can release inflammatory factors,which is involved in the pathogenesis of neonatal infectious diseases and can aggravate the inflammatory reaction in the body,and will also damage tissues and organs to varying degrees.Inhibition of pyroptosis can alleviate local tissue inflammation and improve the clinical symptoms of the children.Therefore,in-depth study on the mechanism of pyroptosis in neonatal infectious diseases can provide new ideas for the clinical diagnosis and treatment of diseases and improve the prognosis of the children.

关 键 词：感染性疾病 细胞焦亡 新生儿 

分 类 号：R722.13[医药卫生—儿科]