不同剂量来曲唑联合低分子肝素钙治疗多囊卵巢综合征不孕症患者的疗效分析  

Efficacy Analysis of Different Doses of Letrozole Combined with Low Molecular Heparin Calcium in Treating Infertility Patients with Polycystic Ovary Syndrome

作　　者：陆丰华 周丽琴[1] LU Fenghua;ZHOU Liqin(Department of Obstetrics and Gynecology,Xiangcheng People's Hospital,Suzhou,Jiangsu Province,215131 China)

机构地区：[1]苏州市相城人民医院妇产科,江苏苏州215131

出　　处：《中外医疗》2023年第33期13-17,共5页China & Foreign Medical Treatment

摘　　要：目的 分析不同剂量来曲唑联合低分子肝素钙对多囊卵巢综合征不孕症的疗效。方法 方便选取2018年12月—2020年12月苏州市相城人民医院收治的116例多囊卵巢综合征不孕症患者为研究对象,按随机数表法将其分成对照组和观察组,各58例。两组均采取来曲唑联合低分子肝素钙治疗,对照组来曲唑的剂量为2.5 mg,观察组为5 mg。比较两组干预后检测卵黄体生成素、泌乳素、雌二醇、空腹血糖、睾酮和促卵泡刺激素水平,并评估两组的痤疮、体质量升高、情绪暴躁、女性型脱发、月经周期不规律和毛发生长旺盛症状评分,并比较两组治疗后的妊娠率、卵泡生长速率、排卵率和自然流产率。结果 治疗后,两组的血清卵黄体生成素、泌乳素、雌二醇、空腹血糖、睾酮和促卵泡刺激素水平均明显改善,且对照组各指标水平[(12.47±1.16)U/L、(5.93±1.25)μg/L、(81.15±13.43)ng/L、(6.25±0.32)mmol/L、(1.02±0.14)nmol/L、(6.27±0.34)U/L]均差于观察组,差异有统计学意义(t=18.489、12.465、4.568、13.325、13.217、12.121,P<0.05);治疗后,两组的面部痤疮、体质量升高、情绪暴躁、黑棘皮征、月经周期不规律和毛发生长旺盛症状评分均明显降低,且观察组各项评分[(2.25±0.24)分、(1.43±0.17)分、(1.49±0.17)分、(1.25±0.13)分、(1.72±0.28)分、(1.34±0.15分)]更低,差异有统计学意义(t=14.335、17.652、21.412、25.683、12.932、19.972,P<0.05)。治疗后,观察组卵泡生长速率[(1.87±0.24)mm/d]、妊娠率(68.97%)、排卵率(79.31%)明显高于对照组,自然流产率(5.00%)明显低于对照组,差异有统计学意义(P<0.05)。结论 5 mg/d剂量的来曲唑联合低分子肝素钙对多囊卵巢综合征不孕症有显著的疗效。Objective To analyze the efficacy of different doses of letrozole combined with low molecular heparin cal-cium on infertility of polycystic ovary syndrome.Methods A total of 116 infertile patients with polycystic ovary syn-drome who were admitted to Suzhou Xiangcheng People's Hospital from December 2018 to December 2020 were con-veniently selected as the study objects and were divided into the control group and the observation group according to the random number table method,with 58 cases in each group.Both groups were treated with letrozole combined with low molecular weight heparin calcium.The dose of letrozole in the control group was 2.5 mg,and that in the observa-tion group was 5 mg.The levels of vitellopoietin,prolactin,estradiol,fasting blood glucose,testosterone and follicle stimulating hormone were compared between the two groups after intervention,and the symptom scores of acne,weight gain,emotional irritability,female pattern alopecia,irregular menstrual cycle and vigorous hair growth were evaluated in the two groups.The pregnancy rate,follicle growth rate,ovulation rate and spontaneous abortion rate were compared between the two groups after treatment.Results After treatment,the levels of serum vitellogenin,prolactin,estradiol,fasting blood glucose,testosterone and follicle-stimulating hormone were significantly improved in both groups,and the level of indicators of the control group[(12.47±1.16)U/L,(5.93±1.25)μg/L,(81.15±13.43)ng/L,(6.25±0.32)mmol/L,(1.02±0.14)nmol/L,(6.27±0.34)U/L]were worse than those of the observation group,the differences were statistically significant(t=18.489,12.465,4.568,13.325,13.217,12.121,P<0.05).After treatment,the symptom scores of facial acne,weight gain,emotional irritability,acanthosis nigricans,irregular menstrual cycle and strong hair growth were significantly decreased in both groups,and the scores of the observation group[(2.25±0.24)points,(1.43±0.17)points,(1.49±0.17)points,(1.25±0.13)points,(1.72±0.28)points,(1.34±0.15)points]were lower,the differe

关 键 词：来曲唑 低分子肝素钙 多囊卵巢综合征不孕症 

分 类 号：R711.6[医药卫生—妇产科学]