Preventive effect of kiwi berry(Actinidia arguta)on loperamide-induced constipation  

作　　者：Jiyue Zhang Bin Li Ningxuan Gao Haikun Li Xingyue Cui Hanqian Jiang Siyi Tang Chenyu Jin Jinlong Tian 

机构地区：[1]College of Food Science,Shenyang Agricultural University,Shenyang 110866,China

出　　处：《Food Science and Human Wellness》2024年第3期1410-1421,共12页食品科学与人类健康（英文）

基　　金：financially supported by National Natural Science Foundation of China (U21A20273);China Agriculture Research System of MOF and MARA (CARS-29);the First Batch of Liaoning“Unveiling Leader”Scientific and Technological Projects (2021JH1/10400036)。

摘　　要：Constipation is a common intestinal disease.Kiwi berries can effectively prevent constipation.However,studies have yet to be done to determine how kiwi berries prevent constipation.For two weeks,mice in this study were continually orally gavaged with kiwi berry,loperamide,or a combination of the 2.This study found that the kiwi group's feces had more water than the constipated mice.In addition,kiwi berries can speed up gastrointestinal transit(GI),shorten the time it takes to pass the first dark stool,and dramatically enhance body weight gain.In the interstitial cells of Caj al(ICC)cells and colon tissues,alterations in the protein expression of vasoactive intestinal peptide(VIP),cyclic adenosine monophosphate(cAMP),protein kinase A(PKA),and aquapcrin-3(AQP3)were found.At 3,6,and 12 h of ICC cells and mouse colon,the kiwi group's VIP,cAMP,PKA,and AQP3 protein expression levels were lower than those of the constipated mice.The kiwi berry can decrease the Firmicutes to Bacteroidetes ratio and boost the diversity and quantity of gut microbiota.By influencing the gut microbiota and VIP-cAMP-PKA-AQP3 signaling pathway,kiwi berries prevent constipation.

关 键 词：Kiwi berry CONSTIPATION VIP-cAMP-PKA-AQP3 Gut microbiota 

分 类 号：TS255.1[轻工技术与工程—农产品加工及贮藏工程]