Lactose-free milk powder can effectively relieve diarrhea symptoms in weaning SD rats and children  

作　　者：Manman Liu Shiwen Han Boya Li Cheng Chen Lu Yao Jung-il Kwon Juan Jin Huilian Che 

机构地区：[1]Beijing Advanced Innovation Center for Food Nutrition and Human Health,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China [2]Maeil Innovation Center,Maeil Dairies Co.,Ltd.,Seoul 03142,South Korea

出　　处：《Food Science and Human Wellness》2024年第3期1494-1502,共9页食品科学与人类健康（英文）

基　　金：supported by the project of two children’s dairy products (201704810610483)。

摘　　要：Diarrhea has become the leading cause of illness and death among infants and young children in developing countries.Clinically,patients with diarrhea showed damaged intestinal epithelial villi,usually accompanied by lactase deficiency.In this study,we evaluated the therapeutic effects of lactose-free milk powder on rats and children with diarrhea.Antibiotic-associated diarrhea(AAD)model was established by gavage with antibiotic mixture in SD rats,followed by administration of milk powder containing lactose or not.The results showed that lactose-free milk powder ameliorated A AD-related diarrhea symptoms,and accelerated the recovery from diarrhea.And 16S sequencing results indicated lactose-free milk powder contributed to increase theα-andβ-diversity of intestinal flora,and restore the intestinal microbiota disorder.In conclusion,our data demonstrate that lactose-free milk powder could alleviate diarrhea by restoring gut microbiota and intestinal barrier function.

关 键 词：DIARRHEA Lactose-free Milk powder Intestinal barrier Gut microbiota 

分 类 号：TS252.51[轻工技术与工程—农产品加工及贮藏工程]