胃癌中医不同证型的实验室指标分析  

An Analysis of Laboratory Indicators of Different TCM SyndromeTypes of Gastric Cancer

作　　者：曹爽[1] 贾文文[1] 程念[1] 朱劼 王聪[1] 李欣清 康欣[1] 侯天文 CAO Shuang;JIA Wenwen;CHENG Nian;ZHU Jie;WANG Cong;LI Xinqing;KANG Xin;HOU Tianwen(Laboratory Department of Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China;Laboratory Department of the Fourth Affiliated Hospital of Hebei Medical University,Shijiazhuang 050011,China;Laboratory Department of Hebei Yanda Lu Daopei Hospital,Langfang 065201,China)

机构地区：[1]河北省中医院检验科,河北石家庄050011 [2]河北医科大学附属第四医院检验科,河北石家庄050011 [3]河北燕达陆道培医院检验科,河北廊坊065201

出　　处：《标记免疫分析与临床》2023年第10期1712-1715,共4页Labeled Immunoassays and Clinical Medicine

基　　金：河北省中医药管理局科技计划项目:健脾养胃法在胃癌治疗中疗效观察及实验室指标监测(编号:2019018);河北省中医药管理局科技计划项目:化浊解毒中药治疗慢性萎缩性胃炎的(编号:2020062)。

摘　　要：目的探究胃癌相关实验室指标与中医证型之间的关系,为从中医角度分析胃癌提供一些借鉴。方法选取2020年4月至2020年11月在河北省中医院住院的胃癌患者136例,对这些患者进行中医辨证分型,收集这些患者的血清学指标,如CA72-4、CEA、甲胎蛋白、总蛋白、白蛋白、总胆红素、三酰甘油、总胆固醇、葡萄糖、前白蛋白、纤维蛋白原、D-二聚体等。用SPSS软件进行统计学分析,对正态分布采用方差分析,对非正态分布采用非参数分析,以此来研究胃癌不同中医证型与血清学指标的关联性。结果患者男女比例为3∶1,41~65岁人群最易患胃癌,性别和年龄与中医证型均无相关性。其中脾胃虚寒证23例,痰湿凝结证36例,气血两亏证39例,肝胃不和证21例,瘀毒内阻证17例。其中CA72-4在痰湿凝结证和瘀毒内阻证之间,P<0.05,D-二聚体在肝胃不和证和瘀毒内阻证之间,P<0.05,具有统计学意义。结论CA72-4在痰湿凝结证和瘀毒内阻证之间有统计学意义,D-二聚体在肝胃不和证和瘀毒内阻证之间有诊断作用。Objective To evaluate the impact of gastric cancer related laboratory indicators on different TCM syndrome types,in order to prove TCM syndrome types of gastric cancer by detecting these indicators,so as to achieve better therapeutic effect.Methods 136 cases of gastric cancer patients hospitalized in Hebei Provincial Hospital of Traditional Chinese Medicine from April,2020 to November,2020 were selected to carry out TCM syndrome differentiation.We then measured the serological indicators of these patients,including:CA72-4,CEA,alpha fetoprotein,total protein,albumin,total bilirubin,triglyceride,total cholesterol,glucose,prealbumin,fibrinogen,D-dimer.SPSS software was used for statistical analysis.ANOVA was used for normal distribution analysis,and nonparametric analysis was used for non-normal distribution evaluation to study the correlation between different TCM syndrome types and serological indicators of gastric cancer.Results The ratio of male to female was 3∶1 in study cohort.Patients aged 41-65 were most likely to develop gastric cancer.There was no correlation between gender and age and TCM syndrome types.There were 23 cases of spleen stomach deficiency cold syndrome,36 cases of phlegm dampness coagulation syndrome,39 cases of Qi and blood deficiency syndrome,21 cases of liver stomach disharmony syndrome,17 cases of blood stasis and toxin internal obstruction syndrome.Among these patients,CA72-4 was between phlegm dampness congealing syndrome and Blood Stasis Toxin internal obstruction syndrome(P<0.05),and D-dimer was between liver stomach disharmony syndrome and Blood Stasis Toxin internal obstruction syndrome(P<0.05),with a statistically significant difference.Conclusion CA72-4 plays a diagnostic role between phlegm dampness congealing syndrome and Blood Stasis Toxin internal obstruction syndrome,while D-dimer plays a diagnostic role between liver stomach disharmony syndrome and Blood Stasis Toxin internal obstruction syndrome.

关 键 词：胃癌 实验室指标 中医证型 

分 类 号：R735.2[医药卫生—肿瘤]