生物相容性纳米纤维素自愈合水凝胶的构建及其性能  

Fabrication and properties of biocompatible nanocelluloseself-healing hydrogels

作　　者：王汉琛 吴嘉茵 黄彪[1] 卢麒麟[1,2] WANG Hanchen;WU Jiayin;HUANG Biao;LU Qilin(College of Material Engineering,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China;Fujian Key Laboratory of Novel Functional Textile Fibers and Materials,Minjiang University,Fuzhou,Fujian 350108,China)

机构地区：[1]福建农林大学材料工程学院,福建福州350002 [2]闽江学院福建省新型功能性纺织纤维及材料重点实验室,福建福州350108

出　　处：《纺织学报》2023年第12期17-25,共9页Journal of Textile Research

基　　金：国家自然科学基金项目(32301529);福建省科技创新重点项目(高校类)(2021G02011);福建省自然科学基金面上项目(2021J011034);闽江学院引进人才项目(MJY18010)。

摘　　要：针对水凝胶存在力学性能差、受损后性能难以恢复导致使用寿命短,以及有毒交联剂的使用带来生物相容性差的问题,以明胶(Gel)为基质,双醛纳米纤维素(DNCC)为增强相,通过动态亚胺键形成第一重交联网络,并引入单宁(Ta)和四硼酸钠(Borax)形成多重氢键和动态硼酸酯键,基于动态共价键和氢键协同制备了具有三重交联网络的生物相容性纳米纤维素自愈合Gel/DNCC/Borax/Ta水凝胶,并对其结构和性能进行表征。结果表明:Gel/DNCC/Borax/Ta水凝胶具有良好的热稳定性、柔韧性及可注射性,相比于Gel/DNCC水凝胶,其力学性能和胶体黏弹性明显提高,断裂强度从0.138 MPa增加到0.353 MPa,增加了155.7%,储能模量从960 Pa升高到1 550 Pa,提升了61.4%;室温环境下,无需外界刺激,受损的水凝胶能够在1 h内快速愈合,愈合效率达到98%;经质量分数0.5%的明胶纤维素复合物浸提液处理72 h后,成纤维细胞凋亡率小于5%,表明Gel/DNCC/Borax/Ta水凝胶具有良好的生物相容性。Objective Hydrogel materials have a wide range of promising applications in various fields such as drug delivery,tissue healing,and wearable electronic devices because of their soft texture and 3-D porous structure.However,the low durability and poor biocompatibility of traditional hydrogels have limited their practical applications.Therefore,a self-healing hydrogel with good biocompatibility and injectable capacity should be designed to provide novel perspectives to break the current technological bottleneck.Method The self-healing property of hydrogels depends mainly on dynamic chemical bonding,which restores damaged chemical bonds and resumes the hydrogel to its original properties.Biocompatible nanocellulose self-healing hydrogels(Gel/DNCC/Borax/Ta)with triple crosslinking networks were prepared by reversible crosslinking the amino group in gelatin(Gel)and the aldehyde group in dual formaldehyde nanocellulose(DNCC)to form imine bonds as the first crosslinking network.Then tannin(Ta)and borax(Borax)were introduced into the hydrogels to form multiple hydrogen bonding network and dynamic borate ester bonding network.Results The thermal stability of Gel/DNCC/Borax/Ta hydrogels was enhanced compared to gelatin,with the thermal decomposition temperature increasing from 277.3℃to 301.0℃,and the maximum mass loss rate temperature increasing from 312.9℃to 320.9℃.Compared with Gel/DNCC hydrogel,the mechanical properties and colloidal viscoelasticity of Gel/DNCC/Borax/Ta hydrogel were significantly enhanced,with the fracture strength increasing from 0.138 MPa to 0.353 MPa,representing an increase of 155.7%,and the compressive strength increasing from 0.686 MPa to 1.422 MPa,and the energy storage modulus increasing from 960 Pa to 1550 Pa with an increase of 61.4%.The beneficial thermal and mechanical properties of Gel/DNCC/Borax/Ta hydrogels was due to the synergistic effect of multiple hydrogen bonds and dynamic covalent bonds in the hydrogels,forming a compact triple cross-linked network,thus enhancing their str

关 键 词：智能材料 明胶 单宁 四硼酸钠 双醛纳米纤维素 多重氢键 自愈合水凝胶 生物相容性 

分 类 号：TQ352[化学工程]