禽致病性大肠埃希氏菌生物被膜形成的调控机制研究进展  

Progress on the Regulatory Mechanisms of the Biofilm Formation in Avian Pathogenic Escherichia coli

作　　者：于鲁敏 信阳 杨传宗 罗茜 高艳宏 薛挺[2] YU Lu-min;XIN Yang;YANG Chuan-zong;LUO Xi;GAO Yan-hong;XUE Ting(College of Agriculture and Forestry,Linyi University,Linyi,Shandong,276000,China;School of Life Sciences,Anhui Agricultural University,Hefei,Anhui,230036,China)

机构地区：[1]临沂大学农林科学学院,山东临沂276000 [2]安徽农业大学生命科学学院,安徽合肥230036

出　　处：《动物医学进展》2024年第1期100-103,共4页Progress In Veterinary Medicine

基　　金：山东省自然科学基金项目(ZR2022QC115);临沂大学博士科研启动基金项目(LYDX2020BS031);临沂大学大学生创新创业训练计划项目(X202110452097)。

摘　　要：禽致病性大肠埃希氏菌能够引起禽类感染性细菌病,给禽类养殖业造成了重大的经济损失,并严重限制了禽类养殖业的健康发展。为了了解禽致病性大肠埃希氏菌的感染机制,论文简述了生物被膜的形成过程及其危害。细菌生物被膜的形成不但增强细菌对抗菌药物的耐药性,而且导致宿主持续和反复性感染,同时还很难被预防、控制和清除。论文还分析了普遍存在于各类细菌中的重要调控系统——群体感应、双组份系统和第二信使的信号转导途径及其调控机制,并阐述了群体感应、双组份系统和第二信使以及两系统间的互作网络对细菌生物被膜的影响。因此,了解多系统共同调控生物被膜形成的分子机制或许可以作为破坏生物被膜形成的新策略,从而为控制由生物被膜引起的感染和抗菌药物耐药性提供研究方向。Avian pathogenic Escherichia coli(APEC)causes a variety of infectious bacterial diseases,leading to significant economic losses in the poultry industry worldwide and restricting the development of the poultry industry.To gain insight into the mechanism of APEC infection,this paper briefly describes the process of bacterial biofilm formation and its harm.Bacterial biofilms can increase antibiotic resistance to bacteria and result in persistent and recurrent infections in the host,which is difficult to prevent,control,or eradicate.This paper also analyzes the important regulatory systems ubiquitous in all kinds of bacteria——the signal transduction pathways and elucidate the effects of quorum sensing,two-component system,second messenger and an interactive network between two systems on the biofilm formation.Therefore,understanding the molecular mechanisms on multi-system co-regulating the biofilm formation might be a new anti-biofilm strategy to disrupt the biofilm formation,which provides a research direction for controlling the infections and antibiotic resistance caused by biofilms.

关 键 词：禽致病性大肠埃希氏菌 生物被膜 群体感应 双组份系统 第二信使 

分 类 号：S852.612[农业科学—基础兽医学] S858.3[农业科学—兽医学]