线粒体氧化应激在心房颤动电重构机制中的研究进展  

Mitochondrial Oxidative Stress in the Mechanism of Electrical Remodeling of Atrial Fibrillation

作　　者：王洪伟 王贺[3] 卢明凯 陈玉善[3] 关怀敏[4] 解金红[4] WANG Hongwei;WANG He;LU Mingkai;CHEN Yushan;GUAN Huaimin;XIE Jinhong(Henan University of Chinese Medicine,Zhengzhou 450046,Henan,China;Shenzhen Third People’s Hospital,Shenzhen 518112,Guangdong,China;Department of Cardiology,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;Cardiac Center,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]深圳市第三人民医院,广东深圳518112 [3]河南中医药大学第一附属医院心内科,河南郑州450000 [4]河南中医药大学第一附属医院心脏中心,河南郑州450000

出　　处：《心血管病学进展》2023年第12期1079-1083,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金面上项目(81473508);河南省自然科学基金(212300410370)。

摘　　要：线粒体是心肌细胞的发电厂,为心肌细胞的各项活动提供能量,心肌细胞中线粒体的含量较为丰富。近年来越来越多的研究表明,心脏电重构是心律失常的电基础。线粒体发生氧化应激时,线粒体的结构和功能发生改变,引起心房肌细胞的离子通道和缝隙连接通道发生改变,从而导致心房电重构。因此,心房肌细胞线粒体氧化应激在心房电重构过程中发挥着重要作用。Mitochondrion is the power plant of cardiomyocytes,providing energy for the activities of cardiomyocytes.The content of mitochondrion in cardiomyocytes is relatively rich.In recent years,more and more studies have shown that electrical heart remodeling is the electrical basis of arrhythmia.When oxidative stress occurs in mitochondrion,the structure and function of mitochondrion are changed,causing changes in ion channels and gap junction channels of atrial myocytes,thus leading to atrial electrical remodeling.Therefore,oxidative stress of atrial myocyte mitochondrion plays an important role in the process of atrial electroremodeling.

关 键 词：心房颤动 线粒体 氧化应激 电重构 

分 类 号：R541.75[医药卫生—心血管疾病]