胃蛋白酶在声带息肉、声带癌中的作用分析  

Analysis of the Role of Pepsin in Vocal Cord Polyp and Vocal Cord Cancer

作　　者：高竞逾 罗仁婧 阮标[1] 江超武[1] 刘卓慧[1] 龙瑞清 梁秋林 张策 苏路 李鹏 Gao Jingyu;Luo Renjing;Ruan Biao;Jiang Chaowu;Liu Zhuohui;Long Ruiqing;Liang Qiulin;Zhang Ce;Su Lu;Li Peng(不详;Department of the Otolaryngology,the First Affiliated Hospital of Kunming Medical University,Kunming,650032,China)

机构地区：[1]昆明医科大学第一附属医院耳鼻咽喉科,昆明650032 [2]重庆两江新区人民医院耳鼻咽喉科 [3]昆明市延安医院耳鼻咽喉科 [4]昆明市延安医院普外一科

出　　处：《听力学及言语疾病杂志》2024年第1期21-24,共4页Journal of Audiology and Speech Pathology

基　　金：昆明市卫生健康委员会卫生科研项目(2020-04-01-011)。

摘　　要：目的探讨胃蛋白酶在声带息肉、声带癌发病中的作用。方法选取2020年5月至2021年12月诊断为声带息肉患者27例(声带息肉组),声带癌患者27例(声带癌组),健康志愿者23例(对照组);采用反流症状指数(reflux symptom index,RSI)、反流体征评分(reflux finding score,RFS)量表进行评分,胃蛋白酶检测试剂盒(Peptest)进行唾液胃蛋白酶检测,并用免疫组织化学方法检测声带息肉、声带癌患者声带组织中胃蛋白酶表达情况,比较三组RSI、RFS评分、胃蛋白酶检测试剂盒结果,比较声带息肉组和声带癌组胃蛋白酶免疫组化染色结果。结果声带息肉组和声带癌组的RSI、RFS、胃蛋白酶检测结果均高于对照组,差异均有统计学意义(P<0.05);声带息肉组的RSI、胃蛋白酶检测结果和胃蛋白酶免疫组化结果与声带癌组比较差异无统计学意义(P>0.05);声带息肉组的RFS与声带癌组比较差异有统计学意义(P<0.05)。结论胃蛋白酶可能是声带息肉、声带癌的致病因素之一,但发病机制可能有所不同。Objective To investigate the expression of pepsin in vocal cord polyps and vocal cord cancer,and to compare the difference of pepsin expression.Methods From May 2020 to December 2021,27 patients with vocal cord polyp,27 patients with vocal cord cancer and 23 healthy volunteers were selected.RSI and RFS scoring scales were used for scoring,pepsin detection kit was used for saliva pepsin detection,and immunohistochemical methods were used to detect the expression of pepsin in vocal cord tissues of patients with vocal cord polyps and vocal cord cancer.Results The RSI score,RFS score and pepsin test kit results of vocal cord polyp group and vocal cord cancer group were higher than those of non-vocal cord disease group,and the differences of the three indexes were statistically significant(P<0.05).RSI score,pepsin detection kit results and pepsin immunohistochemistry results of vocal cord polyp group showed no significant difference compared with vocal cord cancer group(P>0.05).The RFS score of vocal cord polyp group was significantly different from that of vocal cord cancer group(P<0.05).Conclusion Pepsin may be an important pathogenic factor of vocal cord polyp and vocal cord cancer,and play an important role in the occurrence of these two diseases.The difference of pepsin expression in vocal cord polyp and vocal cord cancer suggests that pepsin may have different pathogenesis.

关 键 词：声带息肉 声带癌 胃蛋白酶 

分 类 号：R767.4[医药卫生—耳鼻咽喉科]