老年性聋发病机制研究进展  

Research Progress on the Etiopathogenesis of Presbycusis

作　　者：王松 韩贺舟 马秀岚[1] Wang Song;Han Hezhou;Ma Xiulan(Shengjing Hospital of China Medical University,Shenyang,110004,China)

机构地区：[1]中国医科大学附属盛京医院耳鼻咽喉头颈外科,沈阳110004

出　　处：《听力学及言语疾病杂志》2024年第1期80-84,共5页Journal of Audiology and Speech Pathology

摘　　要：老年性聋是以隐匿性、缓慢进行性双侧感音神经性听力下降为特征的疾病,其发生和发展是一个多因素作用的过程,每种因素的作用在个体间差异较大。针对老年性聋的发病机制,目前已有一定研究,主要可分为离子通道异常、耳蜗突触病变、活性氧自由基、激素作用、线粒体异常、遗传因素等诸多方面,本文对近年来老年性聋发病机制进行总结。Presbycusis is a disease characterized by hidden and slowly progressive bilateral sensorineural hearing loss.Its occurrence and development is a multifactorial process.The expression of each factor varies greatly among individuals.Currently,there have been some studies on the pathogenesis of presbycusis,which can be categorized into ion channel abnormalities,cochlear synaptopathy,reactive oxygen species,hormone effects,mitochondrial abnormalities,genetic factors and vari other factors.This review summarizes the pathogenesis of presbycusis in recent years.

关 键 词：老年性聋 年龄相关性听力损失 发病机制 

分 类 号：R764.436[医药卫生—耳鼻咽喉科]