单胺氧化酶A(MAOA)在前列腺癌进展中的作用  

Role of monoamine oxidase A in prostate cancer progression

作　　者：陈函沐 李惠 赵菊梅[1] 师长宏 CHEN Hanmu;LI Hui;ZHAO Jumei;SHI Changhong(Medical College of Yan’an University,Yan’an 716000,China;Laboratory Animal Center,the Air Force Medical University,Xi’an 710032)

机构地区：[1]延安大学基础医学院,陕西延安716000 [2]空军军医大学实验动物中心,西安710032

出　　处：《中国实验动物学报》2023年第12期1598-1604,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(32270566,32070532)。

摘　　要：单胺氧化酶A(monoamine oxidase A,MAOA)是一种催化单胺类神经递质和膳食胺氧化脱氨反应的线粒体酶,在神经精神疾病的发病、进展和治疗中发挥着重要作用。最近有研究发现前列腺癌(prostate cancer,PCa)中的MAOA表达升高与肿瘤的进展密切相关,是驱动PCa异质性转化的重要因素。本文主要综述了MAOA在前列腺癌不同病程发展中的作用,包括前列腺癌的发生、发展、侵袭、转移以及耐药。讨论了MAOA在肿瘤微环境中的作用及其抑制剂的潜在用途,进一步提出了在临床前模型中开展基于靶向MAOA的治疗研究,推动相关临床试验,以期为PCa的治疗提供新的潜在治疗靶点。Monoamine oxidase A(MAOA)is a mitochondrial enzyme that catalyzes the oxidative deamination of monoamine neurotransmitters and dietary amines.It plays a crucial role in the pathogenesis,progress,and treatment of neuropsychiatric disorders.Recent studies have revealed that elevated expression of MAOA in prostate cancer(PCa)is closely associated with tumor progression and drives the heterogeneity of PCa.In this review,we summarize the role of MAOA in the development of PCa in different disease stages,including oncogenesis,development,invasion,metastasis,and drug resistance.We also discuss the involvement of MAOA in the tumor microenvironment and explore the potential utility of MAOA inhibitors.We further propose therapeutic strategies based on targeting MAOA in preclinical models to promote relevant clinical trials.This review aims to provide new potential therapeutic targets for the treatment of PCa.

关 键 词：单胺氧化酶A 前列腺癌 异质性 进展 抑制剂 

分 类 号：Q95-33[生物学—动物学]