模式动物斑马鱼在人乳腺癌疾病研究中的应用进展  

Research progress on the application of a zebrafish model in breast cancer research

作　　者：张敏 张晶晶 宁国柱 ZHANG Min;ZHANG Jingjing;NING Guozhu(Affiliated Hospital of Guangdong Medical University&Zhanjiang Key Laboratory of Zebrafish Model for Development and Disease,Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学附属医院湛江市斑马鱼发育与疾病动物模型重点实验室,广东湛江524001

出　　处：《中国实验动物学报》2023年第12期1629-1635,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：湛江市科技发展专项资金(2022A01231)。

摘　　要：斑马鱼异种移植模型在乳腺癌的研究中具有重要的价值,能够密切观察肿瘤细胞生长、转移以及与免疫系统的相互作用,为乳腺癌治疗提供新的思路和实验依据。此外,斑马鱼模型还可以用于高通量药物的筛选。本篇综述归纳和总结了斑马鱼异种移植模型在乳腺癌发生发展中的机制研究进展,以及抗肿瘤药物在乳腺癌斑马鱼异种移植模型中的相关筛选和治疗研究进展。The zebrafish xenograft model plays an important role in cancer modelling,especially breast cancer xenografts.This model facilitates the real-time observation of tumor cell growth,metastasis,and interactions with the immune system,thus providing novel insights and experimental foundations for breast cancer treatment.Furthermore,the zebrafish xenograft model offers a valuable tool for high-throughput drug screening.This review provides an overview of the contributions of the zebrafish xenograft model to elucidating the mechanisms underlying breast cancer development,and its use in screening anti-tumor drugs and conducting therapeutic research.

关 键 词：斑马鱼 异种移植模型 乳腺癌 

分 类 号：Q95-33[生物学—动物学]